Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury
<b>Objective</b>: Fluctuations in sodium levels (SLs) may increase mortality, severity, and prolonged length of stay (LOS) in critically ill patients. We aim to study the effect of SL on various clinical outcomes in patients with severe traumatic brain injury (TBI). <b>Methods</...
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2025-01-01
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| author | Bharti Sharma Winston Jiang Munirah M. Hasan George Agriantonis Navin D. Bhatia Zahra Shafaee Kate Twelker Jennifer Whittington |
| author_facet | Bharti Sharma Winston Jiang Munirah M. Hasan George Agriantonis Navin D. Bhatia Zahra Shafaee Kate Twelker Jennifer Whittington |
| author_sort | Bharti Sharma |
| collection | DOAJ |
| description | <b>Objective</b>: Fluctuations in sodium levels (SLs) may increase mortality, severity, and prolonged length of stay (LOS) in critically ill patients. We aim to study the effect of SL on various clinical outcomes in patients with severe traumatic brain injury (TBI). <b>Methods</b>: This is a single-center, retrospective study of patients with severe TBI from 1 January 2020 to 31 December 2023, inclusive. Patients were identified using Abbreviated Injury Severity (AIS) scores and International Classification of Diseases (ICD) injury descriptions. <b>Result</b>: Variations in hospital (H) admission SLs were statistically significant across four age ranges (pediatric, young adult, older adults, and elderly). Intensive care unit (ICU) admission, H discharge, and death also showed significance. A statistical difference was noted in ICU discharge levels while comparing blunt versus penetrating injury. We found statistically significant differences in SLs at H admission, ICU admission, and ICU discharge when compared to the Injury Severity Score (ISS) and the Glasgow Coma Scale (GCS) at admission. A linear regression analysis revealed a statistically significant positive correlation between ICU admission SLs and ISS. We discovered statistically significant differences when comparing ICU admission levels to H LOS, ventilator days, and mortality. <b>Conclusions</b>: SL upon ICU admission is correlated with ISS, GCS, and mortality rates. The elevated admission SL was linked to adverse hospital outcomes, including prolonged LOS at the H, ICU, and mechanical ventilation. Moreover, variability in serum SLs is independently associated with mortality throughout the hospital stay, irrespective of the absolute serum sodium concentration. |
| format | Article |
| id | doaj-art-fa98afd7b4474830b3abbfb40de5f104 |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-fa98afd7b4474830b3abbfb40de5f1042025-01-24T13:28:48ZengMDPI AGDiagnostics2075-44182025-01-0115212510.3390/diagnostics15020125Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain InjuryBharti Sharma0Winston Jiang1Munirah M. Hasan2George Agriantonis3Navin D. Bhatia4Zahra Shafaee5Kate Twelker6Jennifer Whittington7Elmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USAElmhurst Hospital Center, Trauma Unit, Department of Surgery, NYC Health & Hospitals, New York, NY 11373, USA<b>Objective</b>: Fluctuations in sodium levels (SLs) may increase mortality, severity, and prolonged length of stay (LOS) in critically ill patients. We aim to study the effect of SL on various clinical outcomes in patients with severe traumatic brain injury (TBI). <b>Methods</b>: This is a single-center, retrospective study of patients with severe TBI from 1 January 2020 to 31 December 2023, inclusive. Patients were identified using Abbreviated Injury Severity (AIS) scores and International Classification of Diseases (ICD) injury descriptions. <b>Result</b>: Variations in hospital (H) admission SLs were statistically significant across four age ranges (pediatric, young adult, older adults, and elderly). Intensive care unit (ICU) admission, H discharge, and death also showed significance. A statistical difference was noted in ICU discharge levels while comparing blunt versus penetrating injury. We found statistically significant differences in SLs at H admission, ICU admission, and ICU discharge when compared to the Injury Severity Score (ISS) and the Glasgow Coma Scale (GCS) at admission. A linear regression analysis revealed a statistically significant positive correlation between ICU admission SLs and ISS. We discovered statistically significant differences when comparing ICU admission levels to H LOS, ventilator days, and mortality. <b>Conclusions</b>: SL upon ICU admission is correlated with ISS, GCS, and mortality rates. The elevated admission SL was linked to adverse hospital outcomes, including prolonged LOS at the H, ICU, and mechanical ventilation. Moreover, variability in serum SLs is independently associated with mortality throughout the hospital stay, irrespective of the absolute serum sodium concentration.https://www.mdpi.com/2075-4418/15/2/125sodium levelshypernatremiatraumatic brain injuryinjury severity scoresevere trauma |
| spellingShingle | Bharti Sharma Winston Jiang Munirah M. Hasan George Agriantonis Navin D. Bhatia Zahra Shafaee Kate Twelker Jennifer Whittington Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury Diagnostics sodium levels hypernatremia traumatic brain injury injury severity score severe trauma |
| title | Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury |
| title_full | Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury |
| title_fullStr | Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury |
| title_full_unstemmed | Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury |
| title_short | Natremia Significantly Influences the Clinical Outcomes in Patients with Severe Traumatic Brain Injury |
| title_sort | natremia significantly influences the clinical outcomes in patients with severe traumatic brain injury |
| topic | sodium levels hypernatremia traumatic brain injury injury severity score severe trauma |
| url | https://www.mdpi.com/2075-4418/15/2/125 |
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