Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review
Fluoroquinolones are commonly prescribed antimicrobials that have been implicated in alterations of glucose metabolism. We report a case of refractory fluoroquinolone-induced hypoglycemia in a patient with type-2 diabetes mellitus on glipizide that was successfully treated with octreotide. A patient...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2019/3560608 |
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| author | Matthew R. Watson Ceressa T. Ward Amit Prabhakar Babar Fiza Vanessa Moll |
| author_facet | Matthew R. Watson Ceressa T. Ward Amit Prabhakar Babar Fiza Vanessa Moll |
| author_sort | Matthew R. Watson |
| collection | DOAJ |
| description | Fluoroquinolones are commonly prescribed antimicrobials that have been implicated in alterations of glucose metabolism. We report a case of refractory fluoroquinolone-induced hypoglycemia in a patient with type-2 diabetes mellitus on glipizide that was successfully treated with octreotide. A patient was admitted with hypoglycemia after having been initiated on levofloxacin therapy. Despite treating the hypoglycemia supportively with multiple boluses of 25 g of dextrose, a continuous dextrose infusion, and glucagon, the patient experienced repeated episodes of rebound hypoglycemia. The persistent hypoglycemia was eventually reversed with the administration of subcutaneous octreotide. Clinicians should be cognizant of this adverse effect of fluoroquinolones, as well as predisposing risk factors, and consider octreotide as an adjunctive therapy for refractory hypoglycemia cases. |
| format | Article |
| id | doaj-art-fa9768e4e4424c7d8281b52992fac671 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-fa9768e4e4424c7d8281b52992fac6712025-02-03T06:13:12ZengWileyCase Reports in Critical Care2090-64202090-64392019-01-01201910.1155/2019/35606083560608Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature ReviewMatthew R. Watson0Ceressa T. Ward1Amit Prabhakar2Babar Fiza3Vanessa Moll4Pharmaceutical Services, Emory University Hospital Midtown, Atlanta, Georgia, USAPharmaceutical Services, Emory University Hospital Midtown, Atlanta, Georgia, USADepartment of Anesthesiology, Emory Center of Critical Care, Emory School of Medicine, Atlanta, Georgia, USADepartment of Anesthesiology, Emory Center of Critical Care, Emory School of Medicine, Atlanta, Georgia, USADepartment of Anesthesiology, Emory Center of Critical Care, Emory School of Medicine, Atlanta, Georgia, USAFluoroquinolones are commonly prescribed antimicrobials that have been implicated in alterations of glucose metabolism. We report a case of refractory fluoroquinolone-induced hypoglycemia in a patient with type-2 diabetes mellitus on glipizide that was successfully treated with octreotide. A patient was admitted with hypoglycemia after having been initiated on levofloxacin therapy. Despite treating the hypoglycemia supportively with multiple boluses of 25 g of dextrose, a continuous dextrose infusion, and glucagon, the patient experienced repeated episodes of rebound hypoglycemia. The persistent hypoglycemia was eventually reversed with the administration of subcutaneous octreotide. Clinicians should be cognizant of this adverse effect of fluoroquinolones, as well as predisposing risk factors, and consider octreotide as an adjunctive therapy for refractory hypoglycemia cases.http://dx.doi.org/10.1155/2019/3560608 |
| spellingShingle | Matthew R. Watson Ceressa T. Ward Amit Prabhakar Babar Fiza Vanessa Moll Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review Case Reports in Critical Care |
| title | Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review |
| title_full | Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review |
| title_fullStr | Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review |
| title_full_unstemmed | Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review |
| title_short | Successful Use of Octreotide Therapy for Refractory Levofloxacin-Induced Hypoglycemia: A Case Report and Literature Review |
| title_sort | successful use of octreotide therapy for refractory levofloxacin induced hypoglycemia a case report and literature review |
| url | http://dx.doi.org/10.1155/2019/3560608 |
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