Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia
Objective. To examine conjunctival lymphatic vessels and to analyze the relationship between lymphangiogenesis and aggressive recurrent pterygia. Methods. Tissues from 60 excised recurrent (including 19 of Grade 1, 28 of Grade 2, and 13 of Grade 3) pterygia were used in the study. Tissues from 9 nas...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2016/1592514 |
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| _version_ | 1832545755533934592 |
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| author | Wei Zhao Tao Wang Juan Deng Lei Zhong Weilan Huang Shiqi Ling |
| author_facet | Wei Zhao Tao Wang Juan Deng Lei Zhong Weilan Huang Shiqi Ling |
| author_sort | Wei Zhao |
| collection | DOAJ |
| description | Objective. To examine conjunctival lymphatic vessels and to analyze the relationship between lymphangiogenesis and aggressive recurrent pterygia. Methods. Tissues from 60 excised recurrent (including 19 of Grade 1, 28 of Grade 2, and 13 of Grade 3) pterygia were used in the study. Tissues from 9 nasal epibulbar conjunctivae segments were used as controls. Pterygium slices from each patient were immunostained with LYVE-1 monoclonal antibodies to identify lymphatic microvessels in order to calculate the lymphovascular area (LVA), the lymphatic microvessel density (LMD), and the lymphovascular luminal diameter (LVL). The relationship between lymphangiogenesis (LVA, LMD, and LVL) and pterygium aggression (width, extension, and area) was clarified. Results. Few LYVE-1 positive lymphatic vessels were found in the normal epibulbar conjunctiva segments. Lymphatic vessels were slightly increased in Grades 1 and 2 and were dramatically increased in Grade 3 recurrent pterygia. The LMD was correlated with the pterygium area in Grade 1 and 2 pterygia. In Grade 3, both LVA and LMD were significantly correlated with the pterygium area. Conclusions. Lymphangiogenesis was associated with the degree of aggression in recurrent pterygia, particularly in substantial Grade 3 recurrent pterygia. |
| format | Article |
| id | doaj-art-fa9004576abf4caf8e32252093e54ec7 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-fa9004576abf4caf8e32252093e54ec72025-02-03T07:24:54ZengWileyJournal of Ophthalmology2090-004X2090-00582016-01-01201610.1155/2016/15925141592514Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent PterygiaWei Zhao0Tao Wang1Juan Deng2Lei Zhong3Weilan Huang4Shiqi Ling5Department of Ophthalmology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510623, ChinaDepartment of Ophthalmology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, ChinaDepartment of Ophthalmology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, ChinaDepartment of Ophthalmology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, ChinaDepartment of Ophthalmology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, ChinaDepartment of Ophthalmology, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, ChinaObjective. To examine conjunctival lymphatic vessels and to analyze the relationship between lymphangiogenesis and aggressive recurrent pterygia. Methods. Tissues from 60 excised recurrent (including 19 of Grade 1, 28 of Grade 2, and 13 of Grade 3) pterygia were used in the study. Tissues from 9 nasal epibulbar conjunctivae segments were used as controls. Pterygium slices from each patient were immunostained with LYVE-1 monoclonal antibodies to identify lymphatic microvessels in order to calculate the lymphovascular area (LVA), the lymphatic microvessel density (LMD), and the lymphovascular luminal diameter (LVL). The relationship between lymphangiogenesis (LVA, LMD, and LVL) and pterygium aggression (width, extension, and area) was clarified. Results. Few LYVE-1 positive lymphatic vessels were found in the normal epibulbar conjunctiva segments. Lymphatic vessels were slightly increased in Grades 1 and 2 and were dramatically increased in Grade 3 recurrent pterygia. The LMD was correlated with the pterygium area in Grade 1 and 2 pterygia. In Grade 3, both LVA and LMD were significantly correlated with the pterygium area. Conclusions. Lymphangiogenesis was associated with the degree of aggression in recurrent pterygia, particularly in substantial Grade 3 recurrent pterygia.http://dx.doi.org/10.1155/2016/1592514 |
| spellingShingle | Wei Zhao Tao Wang Juan Deng Lei Zhong Weilan Huang Shiqi Ling Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia Journal of Ophthalmology |
| title | Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia |
| title_full | Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia |
| title_fullStr | Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia |
| title_full_unstemmed | Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia |
| title_short | Conjunctival Lymphangiogenesis Was Associated with the Degree of Aggression in Substantial Recurrent Pterygia |
| title_sort | conjunctival lymphangiogenesis was associated with the degree of aggression in substantial recurrent pterygia |
| url | http://dx.doi.org/10.1155/2016/1592514 |
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