Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment
Skin and soft tissue infections are common presentations for non-tuberculous mycobacteria (NTM). The cutaneous infections caused by NTM may cause localized or diffuse lesions. M. ulcerans is one of the most identified pathogens that involves in the skin and soft tissue mycobacterial infections. Mea...
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| Format: | Article |
| Language: | English |
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HH Publisher
2020-09-01
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| Series: | Progress in Microbes and Molecular Biology |
| Online Access: | https://journals.hh-publisher.com/index.php/pmmb/article/view/316 |
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| _version_ | 1832541450228727808 |
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| author | Loh Teng-Hern Tan Pendru Raghunath Long Chiau Ming Jodi Woan-Fei Law |
| author_facet | Loh Teng-Hern Tan Pendru Raghunath Long Chiau Ming Jodi Woan-Fei Law |
| author_sort | Loh Teng-Hern Tan |
| collection | DOAJ |
| description |
Skin and soft tissue infections are common presentations for non-tuberculous mycobacteria (NTM). The cutaneous infections caused by NTM may cause localized or diffuse lesions. M. ulcerans is one of the most identified pathogens that involves in the skin and soft tissue mycobacterial infections. Meanwhile, M. marinum, as an NTM has also become important emerging causal agents of cutaneous disease in various geographical regions. Although having common ancestry and highly similar in genetic makeup, M. ulcerans and M. marinum have differential impacts on the host innate immune system. In term pathogenesis, prolonged cell exposure to exotoxin mycolactone produced by M. ulcerans could lead to Buruli ulcer. Meanwhile, like most pathogenic mycobacteria, M. marinum evades the host immune responses by invading and replicating inside host cells and it is capable of modulating host immune responses. This article aims to provide a general overview and comparisons between the pathogenesis, diagnosis, prevention and therapeutic strategies for M. ulcerans and M. marinum.
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| format | Article |
| id | doaj-art-fa8d95e6609f44e393151848541bf796 |
| institution | Kabale University |
| issn | 2637-1049 |
| language | English |
| publishDate | 2020-09-01 |
| publisher | HH Publisher |
| record_format | Article |
| series | Progress in Microbes and Molecular Biology |
| spelling | doaj-art-fa8d95e6609f44e393151848541bf7962025-02-04T08:37:00ZengHH PublisherProgress in Microbes and Molecular Biology2637-10492020-09-013110.36877/pmmb.a0000114Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and TreatmentLoh Teng-Hern TanPendru RaghunathLong Chiau MingJodi Woan-Fei Law Skin and soft tissue infections are common presentations for non-tuberculous mycobacteria (NTM). The cutaneous infections caused by NTM may cause localized or diffuse lesions. M. ulcerans is one of the most identified pathogens that involves in the skin and soft tissue mycobacterial infections. Meanwhile, M. marinum, as an NTM has also become important emerging causal agents of cutaneous disease in various geographical regions. Although having common ancestry and highly similar in genetic makeup, M. ulcerans and M. marinum have differential impacts on the host innate immune system. In term pathogenesis, prolonged cell exposure to exotoxin mycolactone produced by M. ulcerans could lead to Buruli ulcer. Meanwhile, like most pathogenic mycobacteria, M. marinum evades the host immune responses by invading and replicating inside host cells and it is capable of modulating host immune responses. This article aims to provide a general overview and comparisons between the pathogenesis, diagnosis, prevention and therapeutic strategies for M. ulcerans and M. marinum. https://journals.hh-publisher.com/index.php/pmmb/article/view/316 |
| spellingShingle | Loh Teng-Hern Tan Pendru Raghunath Long Chiau Ming Jodi Woan-Fei Law Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment Progress in Microbes and Molecular Biology |
| title | Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment |
| title_full | Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment |
| title_fullStr | Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment |
| title_full_unstemmed | Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment |
| title_short | Mycobacterium ulcerans and Mycobacterium marinum: Pathogenesis, Diagnosis and Treatment |
| title_sort | mycobacterium ulcerans and mycobacterium marinum pathogenesis diagnosis and treatment |
| url | https://journals.hh-publisher.com/index.php/pmmb/article/view/316 |
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