Assessment of bone remodeling in patients with type 2 diabetes mellitus
Despite higher femoral neck and lumbar spine bone mineral density (BMD), individuals with type 2 diabetes mellitus (DM2) have 1,5-2 times increased fracture risk than in a healthy population. These data suggest that some indicators may be more informative regarding the prediction of low-trauma fract...
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Zaporizhzhia State Medical and Pharmaceutical University
2019-02-01
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| Series: | Zaporožskij Medicinskij Žurnal |
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| Online Access: | http://zmj.zsmu.edu.ua/article/view/155812/155852 |
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| author | Sain Sattar Safarova |
| author_facet | Sain Sattar Safarova |
| author_sort | Sain Sattar Safarova |
| collection | DOAJ |
| description | Despite higher femoral neck and lumbar spine bone mineral density (BMD), individuals with type 2 diabetes mellitus (DM2) have 1,5-2 times increased fracture risk than in a healthy population. These data suggest that some indicators may be more informative regarding the prediction of low-trauma fractures risk, which observed in patients with diabetes mellitus, and BMD measurement does not reflect in essence the real trend towards the development of bone remodeling disorders in these patients.
Aim: to identify complex interdependencies between the bone mineral and organic components and the risk of low-trauma fractures associated with metabolic changes in DM2.
Materials and methods. A cross-sectional study was conducted in patients diagnosed with DM2 (n = 137); the control group consisted of 82 individuals. Calciotropic hormones, serum levels of bone remodeling markers and X-ray densitometry were studied in all the patients.
Results. Patients with DM2 had lower P1NP and b-CTx values, reflecting a slower metabolism of bone tissue compared to the control group. The results of densitometry revealed no significant differences in BMD between the patients with DM2 and control.
Conclusions. High rate of bone remodeling was found at the elevated values of parathyroid hormone with a predominance of bone resorption, which is confirmed by a positive correlation between parathyroid hormone level and the serum biochemical marker of bone resorption. There is a relationship between DM2 duration and a decrease in BMD, which is the most pronounced in men aged up to 50 years. |
| format | Article |
| id | doaj-art-fa8b967065f24fc99b51a0ce185a1aec |
| institution | DOAJ |
| issn | 2306-4145 2310-1210 |
| language | English |
| publishDate | 2019-02-01 |
| publisher | Zaporizhzhia State Medical and Pharmaceutical University |
| record_format | Article |
| series | Zaporožskij Medicinskij Žurnal |
| spelling | doaj-art-fa8b967065f24fc99b51a0ce185a1aec2025-08-20T03:06:28ZengZaporizhzhia State Medical and Pharmaceutical UniversityZaporožskij Medicinskij Žurnal2306-41452310-12102019-02-01211606310.14739/2310-1210.2019.1.155812Assessment of bone remodeling in patients with type 2 diabetes mellitusSain Sattar SafarovaDespite higher femoral neck and lumbar spine bone mineral density (BMD), individuals with type 2 diabetes mellitus (DM2) have 1,5-2 times increased fracture risk than in a healthy population. These data suggest that some indicators may be more informative regarding the prediction of low-trauma fractures risk, which observed in patients with diabetes mellitus, and BMD measurement does not reflect in essence the real trend towards the development of bone remodeling disorders in these patients. Aim: to identify complex interdependencies between the bone mineral and organic components and the risk of low-trauma fractures associated with metabolic changes in DM2. Materials and methods. A cross-sectional study was conducted in patients diagnosed with DM2 (n = 137); the control group consisted of 82 individuals. Calciotropic hormones, serum levels of bone remodeling markers and X-ray densitometry were studied in all the patients. Results. Patients with DM2 had lower P1NP and b-CTx values, reflecting a slower metabolism of bone tissue compared to the control group. The results of densitometry revealed no significant differences in BMD between the patients with DM2 and control. Conclusions. High rate of bone remodeling was found at the elevated values of parathyroid hormone with a predominance of bone resorption, which is confirmed by a positive correlation between parathyroid hormone level and the serum biochemical marker of bone resorption. There is a relationship between DM2 duration and a decrease in BMD, which is the most pronounced in men aged up to 50 years.http://zmj.zsmu.edu.ua/article/view/155812/155852diabetes mellitusbone tissue |
| spellingShingle | Sain Sattar Safarova Assessment of bone remodeling in patients with type 2 diabetes mellitus Zaporožskij Medicinskij Žurnal diabetes mellitus bone tissue |
| title | Assessment of bone remodeling in patients with type 2 diabetes mellitus |
| title_full | Assessment of bone remodeling in patients with type 2 diabetes mellitus |
| title_fullStr | Assessment of bone remodeling in patients with type 2 diabetes mellitus |
| title_full_unstemmed | Assessment of bone remodeling in patients with type 2 diabetes mellitus |
| title_short | Assessment of bone remodeling in patients with type 2 diabetes mellitus |
| title_sort | assessment of bone remodeling in patients with type 2 diabetes mellitus |
| topic | diabetes mellitus bone tissue |
| url | http://zmj.zsmu.edu.ua/article/view/155812/155852 |
| work_keys_str_mv | AT sainsattarsafarova assessmentofboneremodelinginpatientswithtype2diabetesmellitus |