Role of BDNF-mTORC1 Signaling Pathway in Female Depression
Depression is a common psychological and mental disorder, characterized by low mood, slow thinking and low will, and even suicidal tendencies in severe cases. It imposes a huge mental and economic burden on patients and their families, and its prevention and treatment have become an urgent public he...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/6619515 |
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| author | Xianquan An Xiaoxiao Yao Bingjin Li Wei Yang Ranji Cui Guoqing Zhao Yang Jin |
| author_facet | Xianquan An Xiaoxiao Yao Bingjin Li Wei Yang Ranji Cui Guoqing Zhao Yang Jin |
| author_sort | Xianquan An |
| collection | DOAJ |
| description | Depression is a common psychological and mental disorder, characterized by low mood, slow thinking and low will, and even suicidal tendencies in severe cases. It imposes a huge mental and economic burden on patients and their families, and its prevention and treatment have become an urgent public health problem. It is worth noting that there is a significant gender difference in the incidence of depression. Studies have shown that females are far more likely to suffer from depression than males, confirming a close relationship between estrogen and the onset of depression. Moreover, recent studies suggest that the brain-derived neurotrophic factor- (BDNF-) mammalian target of rapamycin complex-1 (mTORC1) signaling pathway is a crucial target pathway for improving depression and mediates the rapid antidepressant-like effects of various antidepressants. However, it is not clear whether the BDNF-mTORC1 signaling pathway mediates the regulation of female depression and how to regulate female depression. Hence, we focused on the modulation of estrogen-BDNF-mTORC1 signaling in depression and its possible mechanisms in recent years. |
| format | Article |
| id | doaj-art-fa7637c1a13542f78e810aebb290eb18 |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-fa7637c1a13542f78e810aebb290eb182025-02-03T06:46:16ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/66195156619515Role of BDNF-mTORC1 Signaling Pathway in Female DepressionXianquan An0Xiaoxiao Yao1Bingjin Li2Wei Yang3Ranji Cui4Guoqing Zhao5Yang Jin6Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, ChinaChina-Japan Union Hospital of Jilin University, ChinaJilin Provincial Key Laboratory on Molecular and Chemical Genetic, Second Hospital of Jilin University, Changchun 130041, ChinaDepression is a common psychological and mental disorder, characterized by low mood, slow thinking and low will, and even suicidal tendencies in severe cases. It imposes a huge mental and economic burden on patients and their families, and its prevention and treatment have become an urgent public health problem. It is worth noting that there is a significant gender difference in the incidence of depression. Studies have shown that females are far more likely to suffer from depression than males, confirming a close relationship between estrogen and the onset of depression. Moreover, recent studies suggest that the brain-derived neurotrophic factor- (BDNF-) mammalian target of rapamycin complex-1 (mTORC1) signaling pathway is a crucial target pathway for improving depression and mediates the rapid antidepressant-like effects of various antidepressants. However, it is not clear whether the BDNF-mTORC1 signaling pathway mediates the regulation of female depression and how to regulate female depression. Hence, we focused on the modulation of estrogen-BDNF-mTORC1 signaling in depression and its possible mechanisms in recent years.http://dx.doi.org/10.1155/2021/6619515 |
| spellingShingle | Xianquan An Xiaoxiao Yao Bingjin Li Wei Yang Ranji Cui Guoqing Zhao Yang Jin Role of BDNF-mTORC1 Signaling Pathway in Female Depression Neural Plasticity |
| title | Role of BDNF-mTORC1 Signaling Pathway in Female Depression |
| title_full | Role of BDNF-mTORC1 Signaling Pathway in Female Depression |
| title_fullStr | Role of BDNF-mTORC1 Signaling Pathway in Female Depression |
| title_full_unstemmed | Role of BDNF-mTORC1 Signaling Pathway in Female Depression |
| title_short | Role of BDNF-mTORC1 Signaling Pathway in Female Depression |
| title_sort | role of bdnf mtorc1 signaling pathway in female depression |
| url | http://dx.doi.org/10.1155/2021/6619515 |
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