A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity

A headspace-gas chromatography method for isopropanol determination in warfarin sodium products as a measure of drug crystallinity

Coumadin® a nd s everal generic products of warfarin s odium (WS) contain the crystalline form (clathrate) in which WS and isopropanol (IPA) are associated in a 2:1 molar ratio. IPA is critical in maintaining the WS crystalline structure. Physicochemical properties of the drug and drug product may c...

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Bibliographic Details
Main Authors: Rahman Ziyaur, Akhtar Sohail, Siddiqui Akhtar, Ciavarella Anthony B., Nguyenpho Agnes, Faustino Patrick J., Khan Mansoor A.
Format: Article
Language:English
Published: Sciendo 2018-03-01
Series:Acta Pharmaceutica
Subjects:
warfarin crystallinity
isopropanol
headspacegas chromatography
Online Access:https://doi.org/10.2478/acph-2018-0001
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