Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure
Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for norm...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/841707 |
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| author | Wei Cui Cui-Ming Sun Pei Liu |
| author_facet | Wei Cui Cui-Ming Sun Pei Liu |
| author_sort | Wei Cui |
| collection | DOAJ |
| description | Brain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. However, the role of TJ in ALF has not been completely understood. This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction. |
| format | Article |
| id | doaj-art-fa5e2ae5b9ad4f9ab8ae7cf8c9df3196 |
| institution | OA Journals |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-fa5e2ae5b9ad4f9ab8ae7cf8c9df31962025-08-20T02:22:44ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/841707841707Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver FailureWei Cui0Cui-Ming Sun1Pei Liu2Department of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital, China Medical University, Shenyang 110001, ChinaBrain edema in acute liver failure (ALF) remains lethal. Cytotoxic mechanisms associated with brain edema have been well recognized, but the role of vasogenic mechanisms of brain edema has not been explored. Intact tight junctions (TJs) between brain capillary endothelial cells are critical for normal BBB function. Recent reports found significant alterations in the tight junction elements including occludin and claudin-5, suggesting a vasogenic injury in the blood-brain barrier (BBB) integrity. However, the role of TJ in ALF has not been completely understood. This paper reviews the role of the paracellular tight junction in the increased selective BBB permeability that leads to brain edema in ALF and furthermore explores the effect of systemic inflammatory cytokines on the tight junction dysfunction.http://dx.doi.org/10.1155/2013/841707 |
| spellingShingle | Wei Cui Cui-Ming Sun Pei Liu Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure Gastroenterology Research and Practice |
| title | Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure |
| title_full | Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure |
| title_fullStr | Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure |
| title_full_unstemmed | Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure |
| title_short | Alterations of Blood-Brain Barrier and Associated Factors in Acute Liver Failure |
| title_sort | alterations of blood brain barrier and associated factors in acute liver failure |
| url | http://dx.doi.org/10.1155/2013/841707 |
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