Regeneration of Zebrafish CNS: Adult Neurogenesis
Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibia...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/5815439 |
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| author | Sukla Ghosh Subhra Prakash Hui |
| author_facet | Sukla Ghosh Subhra Prakash Hui |
| author_sort | Sukla Ghosh |
| collection | DOAJ |
| description | Regeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibians are capable of regenerating a variety of complex organs through epimorphosis. Zebrafish is an excellent animal model, which can repair several organs like damaged retina, severed spinal cord, injured brain and heart, and amputated fins. The focus of the present paper is on spinal cord regeneration in adult zebrafish. We intend to discuss our current understanding of the cellular and molecular mechanism(s) that allows formation of proliferating progenitors and controls neurogenesis, which involve changes in epigenetic and transcription programs. Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system. Injury induced proliferation involves radial glia which proliferate, transcribe embryonic genes, and can give rise to new neurons. Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming. |
| format | Article |
| id | doaj-art-fa4e83d6ffdb4a86884803c793d1483c |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-fa4e83d6ffdb4a86884803c793d1483c2025-02-03T06:13:50ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/58154395815439Regeneration of Zebrafish CNS: Adult NeurogenesisSukla Ghosh0Subhra Prakash Hui1Department of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92 A. P. C. Road, Kolkata 700009, IndiaDepartment of Biophysics, Molecular Biology and Bioinformatics, University of Calcutta, 92 A. P. C. Road, Kolkata 700009, IndiaRegeneration in the animal kingdom is one of the most fascinating problems that have allowed scientists to address many issues of fundamental importance in basic biology. However, we came to know that the regenerative capability may vary across different species. Among vertebrates, fish and amphibians are capable of regenerating a variety of complex organs through epimorphosis. Zebrafish is an excellent animal model, which can repair several organs like damaged retina, severed spinal cord, injured brain and heart, and amputated fins. The focus of the present paper is on spinal cord regeneration in adult zebrafish. We intend to discuss our current understanding of the cellular and molecular mechanism(s) that allows formation of proliferating progenitors and controls neurogenesis, which involve changes in epigenetic and transcription programs. Unlike mammals, zebrafish retains radial glia, a nonneuronal cell type in their adult central nervous system. Injury induced proliferation involves radial glia which proliferate, transcribe embryonic genes, and can give rise to new neurons. Recent technological development of exquisite molecular tools in zebrafish, such as cell ablation, lineage analysis, and novel and substantial microarray, together with advancement in stem cell biology, allowed us to investigate how progenitor cells contribute to the generation of appropriate structures and various underlying mechanisms like reprogramming.http://dx.doi.org/10.1155/2016/5815439 |
| spellingShingle | Sukla Ghosh Subhra Prakash Hui Regeneration of Zebrafish CNS: Adult Neurogenesis Neural Plasticity |
| title | Regeneration of Zebrafish CNS: Adult Neurogenesis |
| title_full | Regeneration of Zebrafish CNS: Adult Neurogenesis |
| title_fullStr | Regeneration of Zebrafish CNS: Adult Neurogenesis |
| title_full_unstemmed | Regeneration of Zebrafish CNS: Adult Neurogenesis |
| title_short | Regeneration of Zebrafish CNS: Adult Neurogenesis |
| title_sort | regeneration of zebrafish cns adult neurogenesis |
| url | http://dx.doi.org/10.1155/2016/5815439 |
| work_keys_str_mv | AT suklaghosh regenerationofzebrafishcnsadultneurogenesis AT subhraprakashhui regenerationofzebrafishcnsadultneurogenesis |