Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse
To circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill infected or tumorigenic cells. A crucial even...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/450291 |
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| author | Pablo A. González Leandro J. Carreño Pablo F. Céspedes Susan M. Bueno Claudia A. Riedel Alexis M. Kalergis |
| author_facet | Pablo A. González Leandro J. Carreño Pablo F. Céspedes Susan M. Bueno Claudia A. Riedel Alexis M. Kalergis |
| author_sort | Pablo A. González |
| collection | DOAJ |
| description | To circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill infected or tumorigenic cells. A crucial event determining the recognition and elimination of detrimental cells is antigen recognition by the T cell receptor (TCR) expressed on the surface of T cells. Upon binding of the TCR to cognate peptide-MHC complexes presented on the surface of antigen presenting cells (APCs), a specialized supramolecular structure known as the immunological synapse (IS) assembles at the T cell-APC interface. Such a structure involves massive redistribution of membrane proteins, including TCR/pMHC complexes, modulatory receptor pairs, and adhesion molecules. Furthermore, assembly of the immunological synapse leads to intracellular events that modulate and define the magnitude and characteristics of the T cell response. Here, we discuss recent literature on the regulation and assembly of IS and the mechanisms evolved by tumors to modulate its function to escape T cell cytotoxicity, as well as novel strategies targeting the IS for therapy. |
| format | Article |
| id | doaj-art-fa3e0aef61b445a4ba07e34dd29a2f13 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-fa3e0aef61b445a4ba07e34dd29a2f132025-02-03T06:05:20ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/450291450291Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological SynapsePablo A. González0Leandro J. Carreño1Pablo F. Céspedes2Susan M. Bueno3Claudia A. Riedel4Alexis M. Kalergis5Millennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins no. 340, Santiago 8331010, ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins no. 340, Santiago 8331010, ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins no. 340, Santiago 8331010, ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins no. 340, Santiago 8331010, ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Ciencias Biológicas, Facultad de Ciencias Biológicas y Facultad de Medicina, Universidad Andrés Bello, ChileMillennium Institute on Immunology and Immunotherapy, Departamento de Genética Molecular y Microbiología, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Avenida Libertador Bernardo O'Higgins no. 340, Santiago 8331010, ChileTo circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill infected or tumorigenic cells. A crucial event determining the recognition and elimination of detrimental cells is antigen recognition by the T cell receptor (TCR) expressed on the surface of T cells. Upon binding of the TCR to cognate peptide-MHC complexes presented on the surface of antigen presenting cells (APCs), a specialized supramolecular structure known as the immunological synapse (IS) assembles at the T cell-APC interface. Such a structure involves massive redistribution of membrane proteins, including TCR/pMHC complexes, modulatory receptor pairs, and adhesion molecules. Furthermore, assembly of the immunological synapse leads to intracellular events that modulate and define the magnitude and characteristics of the T cell response. Here, we discuss recent literature on the regulation and assembly of IS and the mechanisms evolved by tumors to modulate its function to escape T cell cytotoxicity, as well as novel strategies targeting the IS for therapy.http://dx.doi.org/10.1155/2013/450291 |
| spellingShingle | Pablo A. González Leandro J. Carreño Pablo F. Céspedes Susan M. Bueno Claudia A. Riedel Alexis M. Kalergis Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse Clinical and Developmental Immunology |
| title | Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse |
| title_full | Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse |
| title_fullStr | Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse |
| title_full_unstemmed | Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse |
| title_short | Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse |
| title_sort | modulation of tumor immunity by soluble and membrane bound molecules at the immunological synapse |
| url | http://dx.doi.org/10.1155/2013/450291 |
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