Structural insights into the regulation of monomeric and dimeric apelin receptor

Structural insights into the regulation of monomeric and dimeric apelin receptor

Abstract The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer during activation...

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Main Authors: Yang Yue, Lier Liu, Lijie Wu, Chanjuan Xu, Man Na, Shenhui Liu, Yuxuan Liu, Fei Li, Junlin Liu, Songting Shi, Hui Lei, Minxuan Zhao, Tianjie Yang, Wei Ji, Arthur Wang, Michael A. Hanson, Raymond C. Stevens, Jianfeng Liu, Fei Xu
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-55555-6
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https://doi.org/10.1038/s41467-024-55555-6

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