Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.

Lipid phosphate phosphatase 3 regulates adipocyte sphingolipid synthesis, but not developmental adipogenesis or diet-induced obesity in mice.

Dephosphorylation of phosphatidic acid (PA) is the penultimate step in triglyceride synthesis. Adipocytes express soluble intracellular PA-specific phosphatases (Lipins) and broader specificity membrane-associated lipid phosphate phosphatases (LPPs) that can also dephosphorylate PA. Inactivation of...

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Bibliographic Details
Main Authors: Lorenzo Federico, Liping Yang, Jason Brandon, Manikandan Panchatcharam, Hongmei Ren, Paul Mueller, Manjula Sunkara, Diana Escalante-Alcalde, Andrew J Morris, Susan S Smyth
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pone.0198063/1/pone.0198063.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210218%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210218T134758Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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