Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression

Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression

The hypothalamus-pituitary-adrenal (HPA) and gut-brain axes are vital biological pathways in depression. The HPA axis regulates the body's stress response, and chronic stress can lead to overactivation of the HPA axis, resulting in elevated cortisol levels that contribute to neuronal damage, pa...

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Bibliographic Details
Main Authors: Amanda Gollo Bertollo, Camila Ferreira Santos, Margarete Dulce Bagatini, Zuleide Maria Ignácio
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Neuroscience
Subjects:
hypothalamus-pituitary-adrenal axis
gut-brain axis
gut microbiota
depression
stress response
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2025.1541075/full
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