Identification and functional clustering of genes regulating muscle protein degradation from amongst the known C. elegans muscle mutants.

Loss of muscle mass via protein degradation is an important clinical problem but we know little of how muscle protein degradation is regulated genetically. To gain insight our labs developed C. elegans into a model for understanding the regulation of muscle protein degradation. Past studies uncovere...

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Bibliographic Details
Main Authors: Freya Shephard, Ademola A Adenle, Lewis A Jacobson, Nathaniel J Szewczyk
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0024686&type=printable
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