HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV

ABSTRACT HIV-1 unspliced RNA serves two distinct functions during viral replication: it is packaged into particles as the viral genome, and it is translated to generate Gag/Gag-Pol polyproteins required for virus assembly. Recent studies have demonstrated that in cultured cells, HIV-1 uses multiple...

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Bibliographic Details
Main Authors: Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:mBio
Subjects:
human immunodeficiency virus
transcription
unspliced RNA
people living with HIV
RNA packaging
Online Access:https://journals.asm.org/doi/10.1128/mbio.03576-24
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https://journals.asm.org/doi/10.1128/mbio.03576-24

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