Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes
The incidence of gastric tube carcinoma (GTC) after esophagectomy for esophageal carcinoma has increased in recent years. Surgical removal of the reconstructed gastric tube is associated with high mortality, and endoscopic submucosal dissection (ESD) is a promising alternative. There are limited rep...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/1631415 |
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| author | Satoru Hashimoto Hiroki Sato Ken-ichi Mizuno Kazuya Takahashi Masafumi Takatsuna Junji Yokoyama Hiroshi Ichikawa Manabu Takeuchi Masaaki Kobayashi Shuji Terai |
| author_facet | Satoru Hashimoto Hiroki Sato Ken-ichi Mizuno Kazuya Takahashi Masafumi Takatsuna Junji Yokoyama Hiroshi Ichikawa Manabu Takeuchi Masaaki Kobayashi Shuji Terai |
| author_sort | Satoru Hashimoto |
| collection | DOAJ |
| description | The incidence of gastric tube carcinoma (GTC) after esophagectomy for esophageal carcinoma has increased in recent years. Surgical removal of the reconstructed gastric tube is associated with high mortality, and endoscopic submucosal dissection (ESD) is a promising alternative. There are limited reports of ESD for GTC. This study investigated the efficacy and safety of ESD in GTC. This single-center retrospective study examined patients who underwent ESD for GTC after esophagectomy at our institution between 2003 and 2018. The curability of GTC with ESD was evaluated histologically according to the Japanese Gastric Cancer Treatment Guidelines. Patient characteristics and procedural and long-term outcomes were analyzed. Overall, 31 patients (29 men and 2 women; median age, 73 years) with 45 GTC lesions underwent ESD. The mean period between primary esophagectomy and the diagnosis of GTC was 10.6 years. Bleeding during ESD was noted in two patients (6.5%). No other adverse or fatal events such as perforation were noted. Complete resection and curative resection were documented in 80.6% and 48.4% of cases, respectively. The 3-year and 5-year overall survival rates were 67.6% and 47.7%, respectively. The 3-year and 5-year disease-specific survival rates were 100% and 92.9%, respectively. One patient died of GTC, and fourteen patients died of other diseases, including primary carcinoma in five cases. ESD was safe and provided good long-term outcomes in patients with GTC. Regular long-term gastroscopy is required for the early detection of GTC. Patients with GTC after esophagectomy for esophageal carcinoma have a high risk of other primary carcinomas or comorbidities after ESD. |
| format | Article |
| id | doaj-art-fa22336664ee4cb9826f7c83bb037b05 |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-fa22336664ee4cb9826f7c83bb037b052025-02-03T01:07:11ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972022-01-01202210.1155/2022/1631415Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term OutcomesSatoru Hashimoto0Hiroki Sato1Ken-ichi Mizuno2Kazuya Takahashi3Masafumi Takatsuna4Junji Yokoyama5Hiroshi Ichikawa6Manabu Takeuchi7Masaaki Kobayashi8Shuji Terai9Division of Gastroenterology and HepatologyDivision of Gastroenterology and HepatologyDivision of Gastroenterology and HepatologyDivision of Gastroenterology and HepatologyDivision of Gastroenterology and HepatologyDepartment of EndoscopyDivision of Digestive and General SurgeryDepartment of GastroenterologyDepartment of GastroenterologyDivision of Gastroenterology and HepatologyThe incidence of gastric tube carcinoma (GTC) after esophagectomy for esophageal carcinoma has increased in recent years. Surgical removal of the reconstructed gastric tube is associated with high mortality, and endoscopic submucosal dissection (ESD) is a promising alternative. There are limited reports of ESD for GTC. This study investigated the efficacy and safety of ESD in GTC. This single-center retrospective study examined patients who underwent ESD for GTC after esophagectomy at our institution between 2003 and 2018. The curability of GTC with ESD was evaluated histologically according to the Japanese Gastric Cancer Treatment Guidelines. Patient characteristics and procedural and long-term outcomes were analyzed. Overall, 31 patients (29 men and 2 women; median age, 73 years) with 45 GTC lesions underwent ESD. The mean period between primary esophagectomy and the diagnosis of GTC was 10.6 years. Bleeding during ESD was noted in two patients (6.5%). No other adverse or fatal events such as perforation were noted. Complete resection and curative resection were documented in 80.6% and 48.4% of cases, respectively. The 3-year and 5-year overall survival rates were 67.6% and 47.7%, respectively. The 3-year and 5-year disease-specific survival rates were 100% and 92.9%, respectively. One patient died of GTC, and fourteen patients died of other diseases, including primary carcinoma in five cases. ESD was safe and provided good long-term outcomes in patients with GTC. Regular long-term gastroscopy is required for the early detection of GTC. Patients with GTC after esophagectomy for esophageal carcinoma have a high risk of other primary carcinomas or comorbidities after ESD.http://dx.doi.org/10.1155/2022/1631415 |
| spellingShingle | Satoru Hashimoto Hiroki Sato Ken-ichi Mizuno Kazuya Takahashi Masafumi Takatsuna Junji Yokoyama Hiroshi Ichikawa Manabu Takeuchi Masaaki Kobayashi Shuji Terai Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes Canadian Journal of Gastroenterology and Hepatology |
| title | Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes |
| title_full | Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes |
| title_fullStr | Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes |
| title_full_unstemmed | Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes |
| title_short | Endoscopic Submucosal Dissection for Gastric Tube Carcinoma after Esophagectomy Contributes to Long-Term Outcomes |
| title_sort | endoscopic submucosal dissection for gastric tube carcinoma after esophagectomy contributes to long term outcomes |
| url | http://dx.doi.org/10.1155/2022/1631415 |
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