The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton
Despite the clinical implication and high incidence of bone and spinal metastases, the molecular mechanisms behind prostate cancer metastasis to bone and spine are not well understood. In this review the molecular mechanisms that may contribute to the highly metastatic phenotype of prostate cancer a...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2013/418340 |
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| author | Emma Roberts Davina A. F. Cossigny Gerald M. Y. Quan |
| author_facet | Emma Roberts Davina A. F. Cossigny Gerald M. Y. Quan |
| author_sort | Emma Roberts |
| collection | DOAJ |
| description | Despite the clinical implication and high incidence of bone and spinal metastases, the molecular mechanisms behind prostate cancer metastasis to bone and spine are not well understood. In this review the molecular mechanisms that may contribute to the highly metastatic phenotype of prostate cancer are discussed. Proangiogenic factors such as vascular endothelial growth factor (VEGF) have been shown to not only aid in the metastatic capabilities of prostate cancer but also encourage the colonization and growth of prostate tumour cells in the skeleton. The importance of VEGF in the complex process of prostate cancer dissemination to the skeleton is discussed, including its role in the development of the bone premetastatic niche, metastatic tumour cell recognition of bone, and bone remodeling. The expression of VEGF has also been shown to be upregulated in prostate cancer and is associated with clinical stage, Gleason score, tumour stage, progression, metastasis, and survival. Due to the multifaceted effect VEGF has on tumour angiogenesis, tumour cell proliferation, and bone destruction, therapies targeting the VEGF pathways have shown promising clinical application and are being investigated in clinical trials. |
| format | Article |
| id | doaj-art-f9d5c177496448018b13e8f30b41fbf2 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-f9d5c177496448018b13e8f30b41fbf22025-02-03T06:06:15ZengWileyProstate Cancer2090-31112090-312X2013-01-01201310.1155/2013/418340418340The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the SkeletonEmma Roberts0Davina A. F. Cossigny1Gerald M. Y. Quan2Spinal Biology Research Laboratory, University of Melbourne, Department of Surgery, Austin Health, P.O. Box 5555, Heidelberg, VIC 3084, AustraliaSpinal Biology Research Laboratory, University of Melbourne, Department of Surgery, Austin Health, P.O. Box 5555, Heidelberg, VIC 3084, AustraliaSpinal Biology Research Laboratory, University of Melbourne, Department of Surgery, Austin Health, P.O. Box 5555, Heidelberg, VIC 3084, AustraliaDespite the clinical implication and high incidence of bone and spinal metastases, the molecular mechanisms behind prostate cancer metastasis to bone and spine are not well understood. In this review the molecular mechanisms that may contribute to the highly metastatic phenotype of prostate cancer are discussed. Proangiogenic factors such as vascular endothelial growth factor (VEGF) have been shown to not only aid in the metastatic capabilities of prostate cancer but also encourage the colonization and growth of prostate tumour cells in the skeleton. The importance of VEGF in the complex process of prostate cancer dissemination to the skeleton is discussed, including its role in the development of the bone premetastatic niche, metastatic tumour cell recognition of bone, and bone remodeling. The expression of VEGF has also been shown to be upregulated in prostate cancer and is associated with clinical stage, Gleason score, tumour stage, progression, metastasis, and survival. Due to the multifaceted effect VEGF has on tumour angiogenesis, tumour cell proliferation, and bone destruction, therapies targeting the VEGF pathways have shown promising clinical application and are being investigated in clinical trials.http://dx.doi.org/10.1155/2013/418340 |
| spellingShingle | Emma Roberts Davina A. F. Cossigny Gerald M. Y. Quan The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton Prostate Cancer |
| title | The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton |
| title_full | The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton |
| title_fullStr | The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton |
| title_full_unstemmed | The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton |
| title_short | The Role of Vascular Endothelial Growth Factor in Metastatic Prostate Cancer to the Skeleton |
| title_sort | role of vascular endothelial growth factor in metastatic prostate cancer to the skeleton |
| url | http://dx.doi.org/10.1155/2013/418340 |
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