The biological functions of sphingolipids in plant pathogenic fungi.
Sphingolipids are critically significant in a range of biological processes in animals, plants, and fungi. In mammalian cells, they serve as vital components of the plasma membrane (PM) in maintaining its structure, tension, and fluidity. They also play a key role in a wide variety of biological pro...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-11-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1011733 |
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| author | Xue-Ming Zhu Lin Li Jian-Dong Bao Jiao-Yu Wang Asen Daskalov Xiao-Hong Liu Maurizio Del Poeta Fu-Cheng Lin |
| author_facet | Xue-Ming Zhu Lin Li Jian-Dong Bao Jiao-Yu Wang Asen Daskalov Xiao-Hong Liu Maurizio Del Poeta Fu-Cheng Lin |
| author_sort | Xue-Ming Zhu |
| collection | DOAJ |
| description | Sphingolipids are critically significant in a range of biological processes in animals, plants, and fungi. In mammalian cells, they serve as vital components of the plasma membrane (PM) in maintaining its structure, tension, and fluidity. They also play a key role in a wide variety of biological processes, such as intracellular signal transduction, cell polarization, differentiation, and migration. In plants, sphingolipids are important for cell development and for cell response to environmental stresses. In pathogenic fungi, sphingolipids are crucial for the initiation and the development of infection processes afflicting humans. However, our knowledge on the metabolism and function of the sphingolipid metabolic pathway of pathogenic fungi affecting plants is still very limited. In this review, we discuss recent developments on sphingolipid pathways of plant pathogenic fungi, highlighting their uniqueness and similarity with plants and animals. In addition, we discuss recent advances in the research and development of fungal-targeted inhibitors of the sphingolipid pathway, to gain insights on how we can better control the infection process occurring in plants to prevent or/and to treat fungal infections in crops. |
| format | Article |
| id | doaj-art-f9d347361a8747ff846aca0627bce95b |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2023-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-f9d347361a8747ff846aca0627bce95b2025-01-22T05:30:52ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742023-11-011911e101173310.1371/journal.ppat.1011733The biological functions of sphingolipids in plant pathogenic fungi.Xue-Ming ZhuLin LiJian-Dong BaoJiao-Yu WangAsen DaskalovXiao-Hong LiuMaurizio Del PoetaFu-Cheng LinSphingolipids are critically significant in a range of biological processes in animals, plants, and fungi. In mammalian cells, they serve as vital components of the plasma membrane (PM) in maintaining its structure, tension, and fluidity. They also play a key role in a wide variety of biological processes, such as intracellular signal transduction, cell polarization, differentiation, and migration. In plants, sphingolipids are important for cell development and for cell response to environmental stresses. In pathogenic fungi, sphingolipids are crucial for the initiation and the development of infection processes afflicting humans. However, our knowledge on the metabolism and function of the sphingolipid metabolic pathway of pathogenic fungi affecting plants is still very limited. In this review, we discuss recent developments on sphingolipid pathways of plant pathogenic fungi, highlighting their uniqueness and similarity with plants and animals. In addition, we discuss recent advances in the research and development of fungal-targeted inhibitors of the sphingolipid pathway, to gain insights on how we can better control the infection process occurring in plants to prevent or/and to treat fungal infections in crops.https://doi.org/10.1371/journal.ppat.1011733 |
| spellingShingle | Xue-Ming Zhu Lin Li Jian-Dong Bao Jiao-Yu Wang Asen Daskalov Xiao-Hong Liu Maurizio Del Poeta Fu-Cheng Lin The biological functions of sphingolipids in plant pathogenic fungi. PLoS Pathogens |
| title | The biological functions of sphingolipids in plant pathogenic fungi. |
| title_full | The biological functions of sphingolipids in plant pathogenic fungi. |
| title_fullStr | The biological functions of sphingolipids in plant pathogenic fungi. |
| title_full_unstemmed | The biological functions of sphingolipids in plant pathogenic fungi. |
| title_short | The biological functions of sphingolipids in plant pathogenic fungi. |
| title_sort | biological functions of sphingolipids in plant pathogenic fungi |
| url | https://doi.org/10.1371/journal.ppat.1011733 |
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