Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide
Neuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors. The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. In the present study, the capability of deletion of ovarian hormones to induce sicknes...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Neurology Research International |
| Online Access: | http://dx.doi.org/10.1155/2015/627642 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832557069004177408 |
|---|---|
| author | Hamid Azizi-Malekabadi Mahmoud Hosseini Masoume Pourganji Hoda Zabihi Mohsen Saeedjalali Akbar Anaeigoudari |
| author_facet | Hamid Azizi-Malekabadi Mahmoud Hosseini Masoume Pourganji Hoda Zabihi Mohsen Saeedjalali Akbar Anaeigoudari |
| author_sort | Hamid Azizi-Malekabadi |
| collection | DOAJ |
| description | Neuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors. The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. In the present study, the capability of deletion of ovarian hormones to induce sickness-like behaviors in rats was compared with the effect lipopolysaccharide (LPS). The groups were including Sham, OVX, Sham-LPS, and OVX-LPS. The Sham-LPS and OVX-LPS groups were treated with LPS (250 μg/kg) two hours before conducting the behavioral tests. In the forced swimming (FST), the immobility times in both OVX and Sham-LPS groups were higher than that of Sham (P<0.001). In open-field (OP) test, the central crossing number by OVX and Sham-LPS groups were lower than Sham (P<0.001) while there were no significant differences between OVX-LPS and OVX groups. In elevated plus maze (EPM), the percent of entries to the open arm by both OVX and Sham-LPS groups was lower than that of Sham group (P<0.001). The results of present study showed that deletion of ovarian hormones induced sickness behaviors in rats which were comparable to the effects of LPS. Moreover, further investigations are required in order to better understand the mechanism(s) involved. |
| format | Article |
| id | doaj-art-f9c9e53e271344e3bae65a87a7d45d56 |
| institution | Kabale University |
| issn | 2090-1852 2090-1860 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neurology Research International |
| spelling | doaj-art-f9c9e53e271344e3bae65a87a7d45d562025-02-03T05:43:50ZengWileyNeurology Research International2090-18522090-18602015-01-01201510.1155/2015/627642627642Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of LipopolysaccharideHamid Azizi-Malekabadi0Mahmoud Hosseini1Masoume Pourganji2Hoda Zabihi3Mohsen Saeedjalali4Akbar Anaeigoudari5Department of Biology, Faculty of Basic Sciences, Islamic Azad University, Isfahan (Khorasgan) Branch, Isfahan, IranNeurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad 9177947564, IranNeurogenic Inflammation Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranPharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranMashhad Technical Faculty, Technical and Vocational University, Mashhad, IranNeurocognitive Research Center and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Azadi Square, Mashhad 9177947564, IranNeuroimmune factors have been proposed as the contributors to the pathogenesis of sickness behaviors. The effects of female gonadal hormones on both neuroinflammation and depression have also been well considered. In the present study, the capability of deletion of ovarian hormones to induce sickness-like behaviors in rats was compared with the effect lipopolysaccharide (LPS). The groups were including Sham, OVX, Sham-LPS, and OVX-LPS. The Sham-LPS and OVX-LPS groups were treated with LPS (250 μg/kg) two hours before conducting the behavioral tests. In the forced swimming (FST), the immobility times in both OVX and Sham-LPS groups were higher than that of Sham (P<0.001). In open-field (OP) test, the central crossing number by OVX and Sham-LPS groups were lower than Sham (P<0.001) while there were no significant differences between OVX-LPS and OVX groups. In elevated plus maze (EPM), the percent of entries to the open arm by both OVX and Sham-LPS groups was lower than that of Sham group (P<0.001). The results of present study showed that deletion of ovarian hormones induced sickness behaviors in rats which were comparable to the effects of LPS. Moreover, further investigations are required in order to better understand the mechanism(s) involved.http://dx.doi.org/10.1155/2015/627642 |
| spellingShingle | Hamid Azizi-Malekabadi Mahmoud Hosseini Masoume Pourganji Hoda Zabihi Mohsen Saeedjalali Akbar Anaeigoudari Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide Neurology Research International |
| title | Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide |
| title_full | Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide |
| title_fullStr | Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide |
| title_full_unstemmed | Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide |
| title_short | Deletion of Ovarian Hormones Induces a Sickness Behavior in Rats Comparable to the Effect of Lipopolysaccharide |
| title_sort | deletion of ovarian hormones induces a sickness behavior in rats comparable to the effect of lipopolysaccharide |
| url | http://dx.doi.org/10.1155/2015/627642 |
| work_keys_str_mv | AT hamidazizimalekabadi deletionofovarianhormonesinducesasicknessbehaviorinratscomparabletotheeffectoflipopolysaccharide AT mahmoudhosseini deletionofovarianhormonesinducesasicknessbehaviorinratscomparabletotheeffectoflipopolysaccharide AT masoumepourganji deletionofovarianhormonesinducesasicknessbehaviorinratscomparabletotheeffectoflipopolysaccharide AT hodazabihi deletionofovarianhormonesinducesasicknessbehaviorinratscomparabletotheeffectoflipopolysaccharide AT mohsensaeedjalali deletionofovarianhormonesinducesasicknessbehaviorinratscomparabletotheeffectoflipopolysaccharide AT akbaranaeigoudari deletionofovarianhormonesinducesasicknessbehaviorinratscomparabletotheeffectoflipopolysaccharide |