Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

Evaluation of a biomarker for amyotrophic lateral sclerosis derived from a hypomethylated DNA signature of human motor neurons

Abstract Amyotrophic lateral sclerosis (ALS) lacks a specific biomarker, but is defined by relatively selective toxicity to motor neurons (MN). As others have highlighted, this offers an opportunity to develop a sensitive and specific biomarker based on detection of DNA released from dying MN within...

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Bibliographic Details
Main Authors: Calum Harvey, Alicja Nowak, Sai Zhang, Tobias Moll, Annika K Weimer, Aina Mogas Barcons, Cleide Dos Santos Souza, Laura Ferraiuolo, Kevin Kenna, Noah Zaitlen, Christa Caggiano, Pamela J Shaw, Michael P Snyder, Jonathan Mill, Eilis Hannon, Johnathan Cooper-Knock
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Medical Genomics
Subjects:
Amyotrophic lateral sclerosis (ALS)
Biomarker
Cell-free DNA
DNA methylation
Whole-genome bisulfite sequencing
IPSC-derived motor neuron
Online Access:https://doi.org/10.1186/s12920-025-02084-w
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