Mimicking Neural Stem Cell Niche by Biocompatible Substrates
Neural stem cells (NSCs) participate in the maintenance, repair, and regeneration of the central nervous system. During development, the primary NSCs are distributed along the ventricular zone of the neural tube, while, in adults, NSCs are mainly restricted to the subependymal layer of the subventri...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/1513285 |
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| _version_ | 1832564164692803584 |
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| author | Citlalli Regalado-Santiago Enrique Juárez-Aguilar Juan David Olivares-Hernández Elisa Tamariz |
| author_facet | Citlalli Regalado-Santiago Enrique Juárez-Aguilar Juan David Olivares-Hernández Elisa Tamariz |
| author_sort | Citlalli Regalado-Santiago |
| collection | DOAJ |
| description | Neural stem cells (NSCs) participate in the maintenance, repair, and regeneration of the central nervous system. During development, the primary NSCs are distributed along the ventricular zone of the neural tube, while, in adults, NSCs are mainly restricted to the subependymal layer of the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. The circumscribed areas where the NSCs are located contain the secreted proteins and extracellular matrix components that conform their niche. The interplay among the niche elements and NSCs determines the balance between stemness and differentiation, quiescence, and proliferation. The understanding of niche characteristics and how they regulate NSCs activity is critical to building in vitro models that include the relevant components of the in vivo niche and to developing neuroregenerative approaches that consider the extracellular environment of NSCs. This review aims to examine both the current knowledge on neurogenic niche and how it is being used to develop biocompatible substrates for the in vitro and in vivo mimicking of extracellular NSCs conditions. |
| format | Article |
| id | doaj-art-f9b857009e5d4e47bcb090119cd28a83 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-f9b857009e5d4e47bcb090119cd28a832025-02-03T01:11:47ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/15132851513285Mimicking Neural Stem Cell Niche by Biocompatible SubstratesCitlalli Regalado-Santiago0Enrique Juárez-Aguilar1Juan David Olivares-Hernández2Elisa Tamariz3Instituto de Ciencias de la Salud, Universidad Veracruzana, Avenida Luis Castelazo Ayala, s/n, 91190 Xalapa, VER, MexicoInstituto de Ciencias de la Salud, Universidad Veracruzana, Avenida Luis Castelazo Ayala, s/n, 91190 Xalapa, VER, MexicoInstituto de Ciencias de la Salud, Universidad Veracruzana, Avenida Luis Castelazo Ayala, s/n, 91190 Xalapa, VER, MexicoInstituto de Ciencias de la Salud, Universidad Veracruzana, Avenida Luis Castelazo Ayala, s/n, 91190 Xalapa, VER, MexicoNeural stem cells (NSCs) participate in the maintenance, repair, and regeneration of the central nervous system. During development, the primary NSCs are distributed along the ventricular zone of the neural tube, while, in adults, NSCs are mainly restricted to the subependymal layer of the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. The circumscribed areas where the NSCs are located contain the secreted proteins and extracellular matrix components that conform their niche. The interplay among the niche elements and NSCs determines the balance between stemness and differentiation, quiescence, and proliferation. The understanding of niche characteristics and how they regulate NSCs activity is critical to building in vitro models that include the relevant components of the in vivo niche and to developing neuroregenerative approaches that consider the extracellular environment of NSCs. This review aims to examine both the current knowledge on neurogenic niche and how it is being used to develop biocompatible substrates for the in vitro and in vivo mimicking of extracellular NSCs conditions.http://dx.doi.org/10.1155/2016/1513285 |
| spellingShingle | Citlalli Regalado-Santiago Enrique Juárez-Aguilar Juan David Olivares-Hernández Elisa Tamariz Mimicking Neural Stem Cell Niche by Biocompatible Substrates Stem Cells International |
| title | Mimicking Neural Stem Cell Niche by Biocompatible Substrates |
| title_full | Mimicking Neural Stem Cell Niche by Biocompatible Substrates |
| title_fullStr | Mimicking Neural Stem Cell Niche by Biocompatible Substrates |
| title_full_unstemmed | Mimicking Neural Stem Cell Niche by Biocompatible Substrates |
| title_short | Mimicking Neural Stem Cell Niche by Biocompatible Substrates |
| title_sort | mimicking neural stem cell niche by biocompatible substrates |
| url | http://dx.doi.org/10.1155/2016/1513285 |
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