Anterior-posterior systematic deficits of cortical thickness in early-onset schizophrenia
Abstract Schizophrenia is a neurodevelopmental condition with alterations in both sensory and association cortical areas. These alterations have been reported to follow structural connectivity patterning, and to occur in a system-level fashion. Here we investigated whether pathological alterations o...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-05-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-025-08216-3 |
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| Summary: | Abstract Schizophrenia is a neurodevelopmental condition with alterations in both sensory and association cortical areas. These alterations have been reported to follow structural connectivity patterning, and to occur in a system-level fashion. Here we investigated whether pathological alterations of schizophrenia originate from an early disruption of cortical organization. We found a structural covariance gradient axis of cortical thickness discriminated anterior from posterior region and was compressed in early-onset schizophrenia (EOS) patients. Patients showed increased structural covariance between two ends of the anterior-posterior axis, with increased geodesic distance of covarying regions between two ends. Positive symptoms increased with the strengthening of structural covariance between two ends. Our findings revealed a contracted organizational axis in EOS patients, which was attributed to excessive distally coordinated changes between anterior and posterior cortical regions. Our study from a systematic perspective suggests disturbed maturational processes of cortical thickness in EOS, supporting the neurodevelopmental hypothesis of schizophrenia. |
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| ISSN: | 2399-3642 |