The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction?
Venous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). This review...
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2025-01-01
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| Online Access: | https://www.mdpi.com/2073-4409/14/2/144 |
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| author | Marco Paolo Donadini Francesca Calcaterra Erica Romualdi Roberta Ciceri Assunta Cancellara Corrado Lodigiani Monica Bacci Silvia Della Bella Walter Ageno Domenico Mavilio |
| author_facet | Marco Paolo Donadini Francesca Calcaterra Erica Romualdi Roberta Ciceri Assunta Cancellara Corrado Lodigiani Monica Bacci Silvia Della Bella Walter Ageno Domenico Mavilio |
| author_sort | Marco Paolo Donadini |
| collection | DOAJ |
| description | Venous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). This review explores the parallels and differences between venous and arterial thrombosis, with particular attention to the role of unprovoked VTE and its potential links to atherosclerosis and systemic inflammation. A key focus is the role of ED, which is emerging as a critical factor in thrombogenesis across both the venous and arterial systems. We examine the current methods for clinically detecting ED, including the use of biomarkers and advanced imaging techniques. Additionally, we discuss novel research avenues, such as the potential of endothelial colony-forming cells and other innovative methodologies, to further unravel the complex mechanisms of thrombosis. Finally, we propose future clinical scenarios where targeting endothelial health could pave the way for more effective prevention and treatment strategies in thrombosis management. |
| format | Article |
| id | doaj-art-f9ad2eed4ebe4339952bca2b77bfd895 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-f9ad2eed4ebe4339952bca2b77bfd8952025-01-24T13:26:50ZengMDPI AGCells2073-44092025-01-0114214410.3390/cells14020144The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction?Marco Paolo Donadini0Francesca Calcaterra1Erica Romualdi2Roberta Ciceri3Assunta Cancellara4Corrado Lodigiani5Monica Bacci6Silvia Della Bella7Walter Ageno8Domenico Mavilio9Department of Medicine and Surgery, Research Center on Thromboembolic Diseases and Antithrombotic Therapies, University of Insubria, 21100 Varese, ItalyDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, ItalyCentro Trombosi e TAO, Azienda Socio Sanitaria Territoriale dei Sette Laghi, 21100 Varese, ItalyDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, ItalyDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, ItalyCenter for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyCenter for Thrombosis and Hemorrhagic Diseases, IRCCS Humanitas Research Hospital, 20089 Rozzano, ItalyDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, ItalyDepartment of Medicine and Surgery, Research Center on Thromboembolic Diseases and Antithrombotic Therapies, University of Insubria, 21100 Varese, ItalyDepartment of Medical Biotechnologies and Translational Medicine, University of Milan, 20125 Milan, ItalyVenous thromboembolism (VTE) and arterial thrombosis (AT) are distinct yet closely related pathological processes. While traditionally considered separate entities, accumulating evidence suggests that they share common risk factors, such as inflammation and endothelial dysfunction (ED). This review explores the parallels and differences between venous and arterial thrombosis, with particular attention to the role of unprovoked VTE and its potential links to atherosclerosis and systemic inflammation. A key focus is the role of ED, which is emerging as a critical factor in thrombogenesis across both the venous and arterial systems. We examine the current methods for clinically detecting ED, including the use of biomarkers and advanced imaging techniques. Additionally, we discuss novel research avenues, such as the potential of endothelial colony-forming cells and other innovative methodologies, to further unravel the complex mechanisms of thrombosis. Finally, we propose future clinical scenarios where targeting endothelial health could pave the way for more effective prevention and treatment strategies in thrombosis management.https://www.mdpi.com/2073-4409/14/2/144venous thromboembolism (VTE)arterial thrombosis (AT)endothelial dysfunction (ED) |
| spellingShingle | Marco Paolo Donadini Francesca Calcaterra Erica Romualdi Roberta Ciceri Assunta Cancellara Corrado Lodigiani Monica Bacci Silvia Della Bella Walter Ageno Domenico Mavilio The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? Cells venous thromboembolism (VTE) arterial thrombosis (AT) endothelial dysfunction (ED) |
| title | The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? |
| title_full | The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? |
| title_fullStr | The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? |
| title_full_unstemmed | The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? |
| title_short | The Link Between Venous and Arterial Thrombosis: Is There a Role for Endothelial Dysfunction? |
| title_sort | link between venous and arterial thrombosis is there a role for endothelial dysfunction |
| topic | venous thromboembolism (VTE) arterial thrombosis (AT) endothelial dysfunction (ED) |
| url | https://www.mdpi.com/2073-4409/14/2/144 |
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