Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study
The relationship between Hashimoto’s thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2018/9793850 |
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| author | Jan Krátký Jana Ježková Mikuláš Kosák Hana Vítková Jana Bartáková Miloš Mráz Jindřich Lukáš Zdenka Límanová Jan Jiskra |
| author_facet | Jan Krátký Jana Ježková Mikuláš Kosák Hana Vítková Jana Bartáková Miloš Mráz Jindřich Lukáš Zdenka Límanová Jan Jiskra |
| author_sort | Jan Krátký |
| collection | DOAJ |
| description | The relationship between Hashimoto’s thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included. Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs. 27% in controls, P=0.005, anti-TG 35% in TC group vs. 21% in controls, P=0.018), and the TC group had significantly higher TSH (median 1.88 mIU/l vs. 1.21 mIU/l, P<0.001). Using multiple logistic regression, positive anti-TPO was identified as an independent risk factor (OR 2.21, P=0.018), while spontaneously suppressed TSH<0.5 mIU/l was a protective factor (OR 0.3, P=0.01) against TC. In conclusion, nodules in subjects with positive antithyroid antibodies could be considered to have a higher risk of malignancy. However, based on our results, it is not possible to declare that TC is triggered by HT. |
| format | Article |
| id | doaj-art-f9a04dd1b23e4c8e97ceb4bc7138862e |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-f9a04dd1b23e4c8e97ceb4bc7138862e2025-02-03T05:44:29ZengWileyInternational Journal of Endocrinology1687-83371687-83452018-01-01201810.1155/2018/97938509793850Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional StudyJan Krátký0Jana Ježková1Mikuláš Kosák2Hana Vítková3Jana Bartáková4Miloš Mráz5Jindřich Lukáš6Zdenka Límanová7Jan Jiskra83rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech RepublicDialectology Center, Institute of Clinical and Experimental Medicine, Vídeňská 1958, 140 21 Praha 4, Czech RepublicDepartment of ENT, Surgery of Head and Neck, Na Homolce Hospital, Roentgenova 2/37, 150 00 Praha 5, Czech Republic3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech Republic3rd Department of Medicine-Department of Endocrinology and Metabolism, First Faculty of Medicine, Charles University and General University Hospital in Prague, U Nemocnice 1, 128 08 Praha 2, Czech RepublicThe relationship between Hashimoto’s thyroiditis (HT) and thyroid cancer (TC) is a controversial topic; it remains unclear if HT acts as a risk factor of TC. The aim of our study was to compare the presence of HT and thyroid function in patients with TC and benign nodules. We analyzed 2571 patients after fine needle aspiration biopsy of thyroid nodule. Totally, 91 patients with primary TC and 182 sex- and age-matched controls were included. Positive antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were associated with TC (anti-TPO 44% in TC vs. 27% in controls, P=0.005, anti-TG 35% in TC group vs. 21% in controls, P=0.018), and the TC group had significantly higher TSH (median 1.88 mIU/l vs. 1.21 mIU/l, P<0.001). Using multiple logistic regression, positive anti-TPO was identified as an independent risk factor (OR 2.21, P=0.018), while spontaneously suppressed TSH<0.5 mIU/l was a protective factor (OR 0.3, P=0.01) against TC. In conclusion, nodules in subjects with positive antithyroid antibodies could be considered to have a higher risk of malignancy. However, based on our results, it is not possible to declare that TC is triggered by HT.http://dx.doi.org/10.1155/2018/9793850 |
| spellingShingle | Jan Krátký Jana Ježková Mikuláš Kosák Hana Vítková Jana Bartáková Miloš Mráz Jindřich Lukáš Zdenka Límanová Jan Jiskra Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study International Journal of Endocrinology |
| title | Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study |
| title_full | Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study |
| title_fullStr | Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study |
| title_full_unstemmed | Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study |
| title_short | Positive Antithyroid Antibodies and Nonsuppressed TSH Are Associated with Thyroid Cancer: A Retrospective Cross-Sectional Study |
| title_sort | positive antithyroid antibodies and nonsuppressed tsh are associated with thyroid cancer a retrospective cross sectional study |
| url | http://dx.doi.org/10.1155/2018/9793850 |
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