Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients
Purpose. To investigate how pretreatment testosterone levels correlate with progression-free survival, metastasis-free survival, and overall survival in a propensity-adjusted localized prostate cancer population. Methods. Men diagnosed with clinical NCCN-risk stratified very-low, low, intermediate,...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Prostate Cancer |
| Online Access: | http://dx.doi.org/10.1155/2020/8357452 |
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| _version_ | 1832560220186869760 |
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| author | Brittni M. Usera Polly Creveling Jonathan D. Tward |
| author_facet | Brittni M. Usera Polly Creveling Jonathan D. Tward |
| author_sort | Brittni M. Usera |
| collection | DOAJ |
| description | Purpose. To investigate how pretreatment testosterone levels correlate with progression-free survival, metastasis-free survival, and overall survival in a propensity-adjusted localized prostate cancer population. Methods. Men diagnosed with clinical NCCN-risk stratified very-low, low, intermediate, high, and/or very-high risk prostate cancer who had a baseline total serum testosterone level≥100 ng/dl measured within the 100 days preceding the first definitive therapy were identified from our prospectively gathered institutional database. Cohorts below (100–239 ng/dl), within (240–593 ng/dl), or above (594 + ng/dl) one standard deviation from the mean testosterone level (416 ng/dl) were used for comparison. Progression-free, metastasis-free, and overall survival were evaluated. A separate cohort of men not receiving ADT was used to evaluate testosterone recovery after various treatment modalities (surgery, external beam radiation, brachytherapy, or combined EBRT + Brachy). Results. There was no statistically significant difference between the low, average, and high testosterone cohorts for PFS, MFS, or OS. In men not using ADT, there were no statistically significant changes in testosterone levels 1 year after therapy, regardless of therapy type. Conclusion. In men with serum testosterone levels >=100 ng/dl at diagnosis, baseline testosterone does not impact PFS, MFS, or OS. Recovery of testosterone back to baseline is expected for men undergoing either surgery, external beam or brachytherapy, or combined modality radiation when not using ADT. |
| format | Article |
| id | doaj-art-f99f897f963444639fdb8904e2d4fa60 |
| institution | Kabale University |
| issn | 2090-3111 2090-312X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Prostate Cancer |
| spelling | doaj-art-f99f897f963444639fdb8904e2d4fa602025-02-03T01:28:16ZengWileyProstate Cancer2090-31112090-312X2020-01-01202010.1155/2020/83574528357452Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer PatientsBrittni M. Usera0Polly Creveling1Jonathan D. Tward2Department of Radiation Oncology, University of California at Davis, Davis, CA, USACancer Control and Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USADepartment of Radiation Oncology, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USAPurpose. To investigate how pretreatment testosterone levels correlate with progression-free survival, metastasis-free survival, and overall survival in a propensity-adjusted localized prostate cancer population. Methods. Men diagnosed with clinical NCCN-risk stratified very-low, low, intermediate, high, and/or very-high risk prostate cancer who had a baseline total serum testosterone level≥100 ng/dl measured within the 100 days preceding the first definitive therapy were identified from our prospectively gathered institutional database. Cohorts below (100–239 ng/dl), within (240–593 ng/dl), or above (594 + ng/dl) one standard deviation from the mean testosterone level (416 ng/dl) were used for comparison. Progression-free, metastasis-free, and overall survival were evaluated. A separate cohort of men not receiving ADT was used to evaluate testosterone recovery after various treatment modalities (surgery, external beam radiation, brachytherapy, or combined EBRT + Brachy). Results. There was no statistically significant difference between the low, average, and high testosterone cohorts for PFS, MFS, or OS. In men not using ADT, there were no statistically significant changes in testosterone levels 1 year after therapy, regardless of therapy type. Conclusion. In men with serum testosterone levels >=100 ng/dl at diagnosis, baseline testosterone does not impact PFS, MFS, or OS. Recovery of testosterone back to baseline is expected for men undergoing either surgery, external beam or brachytherapy, or combined modality radiation when not using ADT.http://dx.doi.org/10.1155/2020/8357452 |
| spellingShingle | Brittni M. Usera Polly Creveling Jonathan D. Tward Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients Prostate Cancer |
| title | Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients |
| title_full | Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients |
| title_fullStr | Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients |
| title_full_unstemmed | Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients |
| title_short | Impact and Outcomes of Pretreatment Total Serum Testosterone on Localized Prostate Cancer Patients |
| title_sort | impact and outcomes of pretreatment total serum testosterone on localized prostate cancer patients |
| url | http://dx.doi.org/10.1155/2020/8357452 |
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