Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis
A 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnor...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2019/7249237 |
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| author | Eleni Klinaki Ioanna Argyri Georgia Amountza Gerina Ioannidou Despoina Maritsi Anastasia Garoufi George Vartzelis |
| author_facet | Eleni Klinaki Ioanna Argyri Georgia Amountza Gerina Ioannidou Despoina Maritsi Anastasia Garoufi George Vartzelis |
| author_sort | Eleni Klinaki |
| collection | DOAJ |
| description | A 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnormalities. However, she developed encephalopathy with apathy, drowsiness, and generalized slowing in the EEG. Discontinuation of vigabatrin quickly improved her symptoms and reversed the EEG slowing. A high index of suspicion is required in order to diagnose vigabatrin-induced encephalopathy, especially as the underlying disorders of these patients can be erroneously considered the cause of the observed encephalopathy. |
| format | Article |
| id | doaj-art-f99ce8133da9413dbc99192408897dea |
| institution | Kabale University |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-f99ce8133da9413dbc99192408897dea2025-02-03T01:06:39ZengWileyCase Reports in Pediatrics2090-68032090-68112019-01-01201910.1155/2019/72492377249237Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous SclerosisEleni Klinaki0Ioanna Argyri1Georgia Amountza2Gerina Ioannidou3Despoina Maritsi4Anastasia Garoufi5George Vartzelis62nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, Greece2nd Pediatric Department of National and Kapodistrian University of Athens, Children’s Hospital “P. & A. Kyriakou”, Athens, GreeceA 5.5-month-old female infant with tuberous sclerosis complex presented with infantile spasms and was treated with vigabatrin. As her condition did not improve, she was given adrenocorticotropic hormone (ACTH) intramuscularly which stopped the spasms and improved the electroencephalogram (EEG) abnormalities. However, she developed encephalopathy with apathy, drowsiness, and generalized slowing in the EEG. Discontinuation of vigabatrin quickly improved her symptoms and reversed the EEG slowing. A high index of suspicion is required in order to diagnose vigabatrin-induced encephalopathy, especially as the underlying disorders of these patients can be erroneously considered the cause of the observed encephalopathy.http://dx.doi.org/10.1155/2019/7249237 |
| spellingShingle | Eleni Klinaki Ioanna Argyri Georgia Amountza Gerina Ioannidou Despoina Maritsi Anastasia Garoufi George Vartzelis Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis Case Reports in Pediatrics |
| title | Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis |
| title_full | Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis |
| title_fullStr | Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis |
| title_full_unstemmed | Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis |
| title_short | Vigabatrin-Induced Encephalopathy in a 5.5-Month-Old Girl with Infantile Spasms due to Tuberous Sclerosis |
| title_sort | vigabatrin induced encephalopathy in a 5 5 month old girl with infantile spasms due to tuberous sclerosis |
| url | http://dx.doi.org/10.1155/2019/7249237 |
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