Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer
Objectives: There is no consensus on the significance of peritoneal lavage cytology for the prognosis of patients with colorectal cancer. In this prospective multicenter study, we aimed to determine whether positive peritoneal lavage cytology results predict poor patient outcomes and to clarify if t...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Japan Society of Coloproctology
2025-07-01
|
| Series: | Journal of the Anus, Rectum and Colon |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jarc/9/3/9_2024-106/_pdf/-char/en |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850078001831608320 |
|---|---|
| author | Masayasu Kawasaki Masao Kameyama Hirotoshi Kobayashi Kenjiro Kotake Kotaro Maeda Takeshi Suto Hideki Ueno Koji Komori Heita Ozawa Keiji Koda Masayuki Ohue Kenichi Sugihara |
| author_facet | Masayasu Kawasaki Masao Kameyama Hirotoshi Kobayashi Kenjiro Kotake Kotaro Maeda Takeshi Suto Hideki Ueno Koji Komori Heita Ozawa Keiji Koda Masayuki Ohue Kenichi Sugihara |
| author_sort | Masayasu Kawasaki |
| collection | DOAJ |
| description | Objectives: There is no consensus on the significance of peritoneal lavage cytology for the prognosis of patients with colorectal cancer. In this prospective multicenter study, we aimed to determine whether positive peritoneal lavage cytology results predict poor patient outcomes and to clarify if the appropriate timing of cytology is before or after tumor resection.
Methods: Patients diagnosed with pathological stage II or III colorectal cancer between 2013 and 2017 were enrolled in this study. Peritoneal lavage cytology was performed twice, before and after the tumor resection, and the results were analyzed to determine their effect on prognosis and peritoneal recurrence.
Results: We analyzed 1378 patients, and 54 (3.9%) had positive cytology results. Furthermore, 30 patients were positive before tumor resection, 13 after tumor resection, and 11 for both markers. The 5-year relapse-free survival rates (5yRFS) with positive and negative cytology before tumor resection in patients with pStage II were 44.4 and 81.7%, respectively (p=0.0014). The 5-year overall survival rates (5yOS) were 57.1 and 91.6%, respectively (p=0.0046). In Stage III, the 5yRFS and 5yOS between patients with positive and negative cytology did not differ. Patients with positive and negative cytology before tumor resection in pStage II had peritoneal recurrence rates of 11.1 and 1.66%, respectively (p=0.034). These rates were 12.5 and 2.51%, respectively, in patients with pStage III (p=0.011).
Conclusions: A positive cytology result before tumor resection is a prognostic factor in Stage II colorectal cancer and is instrumental in predicting peritoneal recurrence in Stages II and III colorectal cancer. |
| format | Article |
| id | doaj-art-f98e7b5835624fb5a91f54f2e4d3d6da |
| institution | DOAJ |
| issn | 2432-3853 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Japan Society of Coloproctology |
| record_format | Article |
| series | Journal of the Anus, Rectum and Colon |
| spelling | doaj-art-f98e7b5835624fb5a91f54f2e4d3d6da2025-08-20T02:45:41ZengThe Japan Society of ColoproctologyJournal of the Anus, Rectum and Colon2432-38532025-07-019331032010.23922/jarc.2024-1062024-106Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal CancerMasayasu Kawasaki0Masao Kameyama1Hirotoshi Kobayashi2Kenjiro Kotake3Kotaro Maeda4Takeshi Suto5Hideki Ueno6Koji Komori7Heita Ozawa8Keiji Koda9Masayuki Ohue10Kenichi Sugihara11Department of Surgery, Bell Land General HospitalDepartment of Surgery, Bell Land General HospitalDepartment of Surgery, Teikyo University Hospital MizonokuchiDepartment of Surgery, Sano City HospitalInternational Medical Center, Fujita Health University HospitalDepartment of Gastroenterological Surgery, Yamagata Prefectural Central HospitalDepartment of Surgery, National Defense Medical CollegeDepartment of Gastroenterological Surgery, Aichi Cancer Center HospitalDepartment of Surgery, Tochigi Cancer CenterTeikyo University Chiba Medical CenterDepartment of Gastroenterological Surgery, Osaka International Cancer InstituteTokyo Medical and Dental UniversityObjectives: There is no consensus on the significance of peritoneal lavage cytology for the prognosis of patients with colorectal cancer. In this prospective multicenter study, we aimed to determine whether positive peritoneal lavage cytology results predict poor patient outcomes and to clarify if the appropriate timing of cytology is before or after tumor resection. Methods: Patients diagnosed with pathological stage II or III colorectal cancer between 2013 and 2017 were enrolled in this study. Peritoneal lavage cytology was performed twice, before and after the tumor resection, and the results were analyzed to determine their effect on prognosis and peritoneal recurrence. Results: We analyzed 1378 patients, and 54 (3.9%) had positive cytology results. Furthermore, 30 patients were positive before tumor resection, 13 after tumor resection, and 11 for both markers. The 5-year relapse-free survival rates (5yRFS) with positive and negative cytology before tumor resection in patients with pStage II were 44.4 and 81.7%, respectively (p=0.0014). The 5-year overall survival rates (5yOS) were 57.1 and 91.6%, respectively (p=0.0046). In Stage III, the 5yRFS and 5yOS between patients with positive and negative cytology did not differ. Patients with positive and negative cytology before tumor resection in pStage II had peritoneal recurrence rates of 11.1 and 1.66%, respectively (p=0.034). These rates were 12.5 and 2.51%, respectively, in patients with pStage III (p=0.011). Conclusions: A positive cytology result before tumor resection is a prognostic factor in Stage II colorectal cancer and is instrumental in predicting peritoneal recurrence in Stages II and III colorectal cancer.https://www.jstage.jst.go.jp/article/jarc/9/3/9_2024-106/_pdf/-char/encolorectal cancerperitoneal lavage cytologyperitoneal recurrencecytology timingprognostic factor |
| spellingShingle | Masayasu Kawasaki Masao Kameyama Hirotoshi Kobayashi Kenjiro Kotake Kotaro Maeda Takeshi Suto Hideki Ueno Koji Komori Heita Ozawa Keiji Koda Masayuki Ohue Kenichi Sugihara Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer Journal of the Anus, Rectum and Colon colorectal cancer peritoneal lavage cytology peritoneal recurrence cytology timing prognostic factor |
| title | Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer |
| title_full | Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer |
| title_fullStr | Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer |
| title_full_unstemmed | Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer |
| title_short | Investigation of Peritoneal Lavage Cytology before and after Tumor Resection as a Prognostic Factor in Colorectal Cancer |
| title_sort | investigation of peritoneal lavage cytology before and after tumor resection as a prognostic factor in colorectal cancer |
| topic | colorectal cancer peritoneal lavage cytology peritoneal recurrence cytology timing prognostic factor |
| url | https://www.jstage.jst.go.jp/article/jarc/9/3/9_2024-106/_pdf/-char/en |
| work_keys_str_mv | AT masayasukawasaki investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT masaokameyama investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT hirotoshikobayashi investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT kenjirokotake investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT kotaromaeda investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT takeshisuto investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT hidekiueno investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT kojikomori investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT heitaozawa investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT keijikoda investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT masayukiohue investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer AT kenichisugihara investigationofperitoneallavagecytologybeforeandaftertumorresectionasaprognosticfactorincolorectalcancer |