The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs
We examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats responded by increased creatine kinase specific activity (CK) to estradiol-17β (E2), genistein (G), daidzein (D),...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2009/273651 |
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| author | D. Somjen N. Mirsky S. Tamir J. Vaya G. H. Posner A. M. Kaye |
| author_facet | D. Somjen N. Mirsky S. Tamir J. Vaya G. H. Posner A. M. Kaye |
| author_sort | D. Somjen |
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| description | We examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats responded by increased creatine kinase specific activity (CK) to estradiol-17β (E2), genistein (G), daidzein (D), biochainin A (BA), quecertin (Qu), carboxy- G (cG), carboxy- BA (cBA), and raloxifene (Ral). The response was inhibited when Ral was injected together with the estrogens. CK was increased when hormones were injected daily into Ovx rats for 4 different time periods. Pretreatment with the less-calcemic vitamin D analogs JK 1624 F2-2 (JKF) or QW 1624 F2-2 (QW) followed by estrogenic injection resulted in increased response and sensitivity to E2 and loss of inhibition of E2 by Ral. CK was also increased by feeding with E2 or licorice or its components dose- and time- dependent in immature or Ovxrats. Diabetic female rats did not respond to increased doses of E2. In conclusion, rat female pituitary is estrogens-responsive organ, suggesting to consider its response for HRT in postmenopausal women for both beneficial and hazardous aspects. |
| format | Article |
| id | doaj-art-f97c7aad0d024bbf86273db6e8ad4ff6 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-f97c7aad0d024bbf86273db6e8ad4ff62025-02-03T05:44:40ZengWileyInternational Journal of Cell Biology1687-88761687-88842009-01-01200910.1155/2009/273651273651The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic AnalogsD. Somjen0N. Mirsky1S. Tamir2J. Vaya3G. H. Posner4A. M. Kaye5Institute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel-Aviv 64239, IsraelFaculty of Science, University of Haifa, Har-Hacarmel, Haifa 31905, IsraelLaboratory of Natural Compounds for Medical Use, Migal-Galilee Technological Center, Kiryat- Shmona 10200, IsraelLaboratory of Natural Compounds for Medical Use, Migal-Galilee Technological Center, Kiryat- Shmona 10200, IsraelDepartment of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USAInstitute of Endocrinology, Metabolism and Hypertension, Sourasky Medical Center, Tel-Aviv 64239, IsraelWe examined the response of rat female pituitary at different metabolic stages to treatments with estrogenic compounds and vitamin D analogs. Immature or ovariectomized (Ovx) female rats responded by increased creatine kinase specific activity (CK) to estradiol-17β (E2), genistein (G), daidzein (D), biochainin A (BA), quecertin (Qu), carboxy- G (cG), carboxy- BA (cBA), and raloxifene (Ral). The response was inhibited when Ral was injected together with the estrogens. CK was increased when hormones were injected daily into Ovx rats for 4 different time periods. Pretreatment with the less-calcemic vitamin D analogs JK 1624 F2-2 (JKF) or QW 1624 F2-2 (QW) followed by estrogenic injection resulted in increased response and sensitivity to E2 and loss of inhibition of E2 by Ral. CK was also increased by feeding with E2 or licorice or its components dose- and time- dependent in immature or Ovxrats. Diabetic female rats did not respond to increased doses of E2. In conclusion, rat female pituitary is estrogens-responsive organ, suggesting to consider its response for HRT in postmenopausal women for both beneficial and hazardous aspects.http://dx.doi.org/10.1155/2009/273651 |
| spellingShingle | D. Somjen N. Mirsky S. Tamir J. Vaya G. H. Posner A. M. Kaye The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs International Journal of Cell Biology |
| title | The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs |
| title_full | The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs |
| title_fullStr | The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs |
| title_full_unstemmed | The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs |
| title_short | The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs |
| title_sort | response of creatine kinase specific activity in rat pituitary to estrogenic compounds and vitamin d less calcemic analogs |
| url | http://dx.doi.org/10.1155/2009/273651 |
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