Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis
Background. Graft reinfection with hepatitis C (HCV) after liver transplantation is a significant problem in transplant hepatology. This meta-analysis was performed to compare the effectiveness and risk of adverse events of interferon-based therapy with no treatment after liver transplantation. Meth...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2015/206302 |
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| author | Yaqin Chen Gang Wu Hongmin Zhang Hua Xu Hong Li Ling Chen Yixuan Yang Peng Hu Dazhi Zhang Hong Ren Huaidong Hu |
| author_facet | Yaqin Chen Gang Wu Hongmin Zhang Hua Xu Hong Li Ling Chen Yixuan Yang Peng Hu Dazhi Zhang Hong Ren Huaidong Hu |
| author_sort | Yaqin Chen |
| collection | DOAJ |
| description | Background. Graft reinfection with hepatitis C (HCV) after liver transplantation is a significant problem in transplant hepatology. This meta-analysis was performed to compare the effectiveness and risk of adverse events of interferon-based therapy with no treatment after liver transplantation. Methods. We searched electronic databases up to July 31, 2013, to obtain relevant research reports that satisfied the inclusion criteria. Meta-analyses were done on randomized controlled trials (RCTs) and nonrandomized trials. Results. A meta-analysis was performed on 2 RCTs and 2 cohort studies comprising a total of 326 patients (171 of whom accepted interferon-based antiviral therapy). The treatment group was found to have higher virological response (VR) rates than controls at 12, 24, 48, and 72 weeks. Patients in the antiviral group had higher sustained virological response (SVR) rates and lower mean alanine aminotransferase levels relative to controls at 48 weeks, but more total serious adverse events (AEs) than controls. Conclusions. Interferon-based treatment has some efficacy in the treatment of HCV graft reinfection following liver transplantation. |
| format | Article |
| id | doaj-art-f97b18a2558a439e92ff3cdd8d4d1174 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-f97b18a2558a439e92ff3cdd8d4d11742025-02-03T01:20:05ZengWileyGastroenterology Research and Practice1687-61211687-630X2015-01-01201510.1155/2015/206302206302Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-AnalysisYaqin Chen0Gang Wu1Hongmin Zhang2Hua Xu3Hong Li4Ling Chen5Yixuan Yang6Peng Hu7Dazhi Zhang8Hong Ren9Huaidong Hu10Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, The Affiliated Hospital of Luzhou Medical College, Luzhou 646000, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaDepartment of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, ChinaBackground. Graft reinfection with hepatitis C (HCV) after liver transplantation is a significant problem in transplant hepatology. This meta-analysis was performed to compare the effectiveness and risk of adverse events of interferon-based therapy with no treatment after liver transplantation. Methods. We searched electronic databases up to July 31, 2013, to obtain relevant research reports that satisfied the inclusion criteria. Meta-analyses were done on randomized controlled trials (RCTs) and nonrandomized trials. Results. A meta-analysis was performed on 2 RCTs and 2 cohort studies comprising a total of 326 patients (171 of whom accepted interferon-based antiviral therapy). The treatment group was found to have higher virological response (VR) rates than controls at 12, 24, 48, and 72 weeks. Patients in the antiviral group had higher sustained virological response (SVR) rates and lower mean alanine aminotransferase levels relative to controls at 48 weeks, but more total serious adverse events (AEs) than controls. Conclusions. Interferon-based treatment has some efficacy in the treatment of HCV graft reinfection following liver transplantation.http://dx.doi.org/10.1155/2015/206302 |
| spellingShingle | Yaqin Chen Gang Wu Hongmin Zhang Hua Xu Hong Li Ling Chen Yixuan Yang Peng Hu Dazhi Zhang Hong Ren Huaidong Hu Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis Gastroenterology Research and Practice |
| title | Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis |
| title_full | Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis |
| title_fullStr | Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis |
| title_full_unstemmed | Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis |
| title_short | Interferon Treatment of Hepatitis C Reinfection after Liver Transplantation: A Meta-Analysis |
| title_sort | interferon treatment of hepatitis c reinfection after liver transplantation a meta analysis |
| url | http://dx.doi.org/10.1155/2015/206302 |
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