Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma

Ferritin-armed extracellular vesicles with enhanced BBB penetration and tumor-targeting ability for synergistic therapy against glioblastoma

Abstract Glioblastoma multiforme (GBM) is an aggressive brain cancer with a high mortality rate and limited treatment options. Metabolism-based synergistic therapy holds promise for GBM treatment, however, its efficacy is significantly impeded by poor blood-brain barrier (BBB) penetration, inadequat...

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Bibliographic Details
Main Authors: Guihong Lu, Peiling Zhuang, Feng Li, Fan Zhang, Xiaoyan Li, Weixiu Wang, Hui Tan
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Nanobiotechnology
Subjects:
BBB penetration
Dual-targeting
LA metabolic therapy
Multimodal therapy
Glioblastoma
Online Access:https://doi.org/10.1186/s12951-025-03646-x
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