Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity
Introduction. Triple negative breast cancer (TNBC) is biologically aggressive and is associated with a worse prognosis. To understand the impact of race/ethnicity on outcome for patients with TNBC, confounding factors such as socioeconomic status (SES) need to be controlled. We examined the impact o...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Breast Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/764570 |
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| author | Quyen D. Chu Amanda E. Henderson Fred Ampil Benjamin D. L. Li |
| author_facet | Quyen D. Chu Amanda E. Henderson Fred Ampil Benjamin D. L. Li |
| author_sort | Quyen D. Chu |
| collection | DOAJ |
| description | Introduction. Triple negative breast cancer (TNBC) is biologically aggressive and is associated with a worse prognosis. To understand the impact of race/ethnicity on outcome for patients with TNBC, confounding factors such as socioeconomic status (SES) need to be controlled. We examined the impact of race/ethnicity on a cohort of patients of low SES who have TNBC. Methods. 786 patients with Stage 0–III breast cancer were evaluated. Of these, 202 patients had TNBC (26%). Primary endpoints were cancer recurrence and death. ZIP code-based income tract and institutional financial data were used to assess SES. Data were analyzed using Kaplan-Meier survival analysis, log-rank tests, Cox Proportional hazard regression, chi square test, and t-tests. A P value ≤0.05 was considered statistically significant. Results. Of the 468 African-Americans (60%) in the database, 138 had TNBC; 64 of 318 Caucasians had TNBC. 80% of patients had an annual income of ≤$20,000. The 5-year overall survival was 77% for African-American women versus 72% for Caucasian women (𝑃=0.95). On multivariate analysis, race/ethnicity had an impact on disease-free survival (𝑃=0.027) but not on overall survival (𝑃=0.98). Conclusion. In a predominantly indigent population, race/ethnicity had no impact on overall survival for patients with triple negative breast cancer. |
| format | Article |
| id | doaj-art-f96d3d9b8bd74be4ae2a9c8063efcc68 |
| institution | Kabale University |
| issn | 2090-3170 2090-3189 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Breast Cancer |
| spelling | doaj-art-f96d3d9b8bd74be4ae2a9c8063efcc682025-02-03T06:15:14ZengWileyInternational Journal of Breast Cancer2090-31702090-31892012-01-01201210.1155/2012/764570764570Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/EthnicityQuyen D. Chu0Amanda E. Henderson1Fred Ampil2Benjamin D. L. Li3Department of Surgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71103, USADepartment of Surgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71103, USADepartment of Radiology, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71103, USADepartment of Surgery, Louisiana State University Health Sciences Center in Shreveport, Shreveport, LA 71103, USAIntroduction. Triple negative breast cancer (TNBC) is biologically aggressive and is associated with a worse prognosis. To understand the impact of race/ethnicity on outcome for patients with TNBC, confounding factors such as socioeconomic status (SES) need to be controlled. We examined the impact of race/ethnicity on a cohort of patients of low SES who have TNBC. Methods. 786 patients with Stage 0–III breast cancer were evaluated. Of these, 202 patients had TNBC (26%). Primary endpoints were cancer recurrence and death. ZIP code-based income tract and institutional financial data were used to assess SES. Data were analyzed using Kaplan-Meier survival analysis, log-rank tests, Cox Proportional hazard regression, chi square test, and t-tests. A P value ≤0.05 was considered statistically significant. Results. Of the 468 African-Americans (60%) in the database, 138 had TNBC; 64 of 318 Caucasians had TNBC. 80% of patients had an annual income of ≤$20,000. The 5-year overall survival was 77% for African-American women versus 72% for Caucasian women (𝑃=0.95). On multivariate analysis, race/ethnicity had an impact on disease-free survival (𝑃=0.027) but not on overall survival (𝑃=0.98). Conclusion. In a predominantly indigent population, race/ethnicity had no impact on overall survival for patients with triple negative breast cancer.http://dx.doi.org/10.1155/2012/764570 |
| spellingShingle | Quyen D. Chu Amanda E. Henderson Fred Ampil Benjamin D. L. Li Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity International Journal of Breast Cancer |
| title | Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity |
| title_full | Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity |
| title_fullStr | Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity |
| title_full_unstemmed | Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity |
| title_short | Outcome for Patients with Triple-Negative Breast Cancer Is Not Dependent on Race/Ethnicity |
| title_sort | outcome for patients with triple negative breast cancer is not dependent on race ethnicity |
| url | http://dx.doi.org/10.1155/2012/764570 |
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