Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics

Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics

Abstract Lipid Nanoparticles (LNPs) recently emerged as an invaluable RNA delivery platform. With many LNP‐based therapeutics in the pre‐clinical and clinical pipelines, there is extensive research dedicated to improving LNPs. These efforts focus mainly on the tolerability and transfectability of ne...

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Bibliographic Details
Main Authors: Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Advanced Science
Subjects:
colon
genetic medicines
inflammatory bowel disease
lipid nanoparticles
mRNA
targeting
Online Access:https://doi.org/10.1002/advs.202408744
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