Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography

Synthesis and preclinical evaluation of gastrin releasing peptide receptor antagonist [18F]MeTz-PEG2-RM26 for positron emission tomography

Abstract Background The gastrin-releasing peptide receptor (GRPR) is overexpressed in the majority of primary prostate cancer lesions, with persistent expression in lymph nodes and bone metastases, making it a legitimate molecular target for diagnostic imaging and staging. This study presents the sy...

Full description

Saved in:
Bibliographic Details
Main Authors: Panagiotis Kanellopoulos, Fanny Lundmark, Ayman Abouzayed, Lorenzo Jacopo Ilic Balestri, Esther Olaniran Håkansson, Karim Obeid, Luke R. Odell, Vladimir Tolmachev, Ulrika Rosenström, Jonas Eriksson, Anna Orlova
Format: Article
Language:English
Published: SpringerOpen 2025-03-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Fluorine-18
TCO
Tetrazine
IEDDA click chemistry
GRPR
Bombesin
Online Access:https://doi.org/10.1186/s41181-025-00336-9
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s41181-025-00336-9

Similar Items