Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo
Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPD...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2022/5837864 |
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| author | Vanessa Marques Meccatti Larissa de Souza Moura Juliana Guerra Pinto Juliana Ferreira-Strixino Amjad Abu Hasna Lívia Mara Alves Figueiredo-Godoi Juliana Campos Junqueira Maria Cristina Marcucci Lucas de Paula Ramos Claudio Antonio Talge Carvalho Cesar Rogério Pucci Luciane Dias de Oliveira |
| author_facet | Vanessa Marques Meccatti Larissa de Souza Moura Juliana Guerra Pinto Juliana Ferreira-Strixino Amjad Abu Hasna Lívia Mara Alves Figueiredo-Godoi Juliana Campos Junqueira Maria Cristina Marcucci Lucas de Paula Ramos Claudio Antonio Talge Carvalho Cesar Rogério Pucci Luciane Dias de Oliveira |
| author_sort | Vanessa Marques Meccatti |
| collection | DOAJ |
| description | Radiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes “LED” on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model. |
| format | Article |
| id | doaj-art-f95fc735474a44feb2231d187081b161 |
| institution | Kabale University |
| issn | 1687-8736 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-f95fc735474a44feb2231d187081b1612025-02-03T01:07:05ZengWileyInternational Journal of Dentistry1687-87362022-01-01202210.1155/2022/5837864Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In VivoVanessa Marques Meccatti0Larissa de Souza Moura1Juliana Guerra Pinto2Juliana Ferreira-Strixino3Amjad Abu Hasna4Lívia Mara Alves Figueiredo-Godoi5Juliana Campos Junqueira6Maria Cristina Marcucci7Lucas de Paula Ramos8Claudio Antonio Talge Carvalho9Cesar Rogério Pucci10Luciane Dias de Oliveira11Department of Biosciences and Oral DiagnosisDepartment of Biosciences and Oral DiagnosisPhotobiology Applied to Health (PHOTOBIOS)—University of Vale do ParaibaPhotobiology Applied to Health (PHOTOBIOS)—University of Vale do ParaibaDepartment of Restorative DentistryDepartment of Biosciences and Oral DiagnosisDepartment of Biosciences and Oral DiagnosisDepartment of Biosciences and Oral DiagnosisDepartment of Biosciences and Oral DiagnosisDepartment of Restorative DentistryDepartment of Restorative DentistryDepartment of Biosciences and Oral DiagnosisRadiotherapy induces a higher level of Candida spp. colonization, resulting in oral candidiasis. This study aimed to evaluate the phototransformation potential of the glycolic extract of Curcuma longa (C. longa); the antifungal activity of C. longa, curcumin, and antifungal photodynamic therapy (aPDT) with blue light-emitting diodes “LED” on Candida albicans and Candida tropicalis in vitro; and the toxicity of C. longa and curcumin in Galleria mellonella model. In order to confirm the light absorption capacity of the C. longa extract, its phototransformation potential was evaluated. The antifungal effect of C. longa, curcumin, and aPDT was evaluated over Candida spp. Finally, the toxicity of C. longa and curcumin was evaluated on the Galleria mellonella model. The data were analyzed using the GraphPad Prism 5.0 software considering α = 5%. It was found that C. longa, curcumin, and aPDT using blue LED have an antifungal effect over C. albicans and C. tropicalis. The extract of C. longa 100 mg/mL and curcumin 200 μg/mL do not show toxicity on Galleria mellonella model.http://dx.doi.org/10.1155/2022/5837864 |
| spellingShingle | Vanessa Marques Meccatti Larissa de Souza Moura Juliana Guerra Pinto Juliana Ferreira-Strixino Amjad Abu Hasna Lívia Mara Alves Figueiredo-Godoi Juliana Campos Junqueira Maria Cristina Marcucci Lucas de Paula Ramos Claudio Antonio Talge Carvalho Cesar Rogério Pucci Luciane Dias de Oliveira Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo International Journal of Dentistry |
| title | Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo |
| title_full | Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo |
| title_fullStr | Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo |
| title_full_unstemmed | Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo |
| title_short | Curcuma longa L. Extract and Photodynamic Therapy are Effective against Candida spp. and Do Not Show Toxicity In Vivo |
| title_sort | curcuma longa l extract and photodynamic therapy are effective against candida spp and do not show toxicity in vivo |
| url | http://dx.doi.org/10.1155/2022/5837864 |
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