The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives
Fungal infections kill more than 3 million people every year. This high number reflects the significant challenges that treating these diseases worldwide presents. The current arsenal of antifungal drugs is limited and often accompanied by high toxicity to patients, elevated treatment costs, increas...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Microbial Sciences |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517425000033 |
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| author | Cássia Milena de Souza Bárbara Tavares Bezerra Daniel Agreda Mellon Haroldo Cesar de Oliveira |
| author_facet | Cássia Milena de Souza Bárbara Tavares Bezerra Daniel Agreda Mellon Haroldo Cesar de Oliveira |
| author_sort | Cássia Milena de Souza |
| collection | DOAJ |
| description | Fungal infections kill more than 3 million people every year. This high number reflects the significant challenges that treating these diseases worldwide presents. The current arsenal of antifungal drugs is limited and often accompanied by high toxicity to patients, elevated treatment costs, increased frequency of resistance rates, and the emergence of naturally resistant species. These treatment challenges highlight the urgency of developing new antifungal therapies, which could positively impact millions of lives each year globally. Our review offers an overview of the antifungal drugs currently available for treatment, presents the status of new antifungal drugs under clinical study, and explores ahead to future candidates that aim to help address this important global health issue. |
| format | Article |
| id | doaj-art-f95c2b6bab1d4b5d86d465c78868464a |
| institution | Kabale University |
| issn | 2666-5174 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj-art-f95c2b6bab1d4b5d86d465c78868464a2025-01-19T06:26:43ZengElsevierCurrent Research in Microbial Sciences2666-51742025-01-018100341The evolution of antifungal therapy: Traditional agents, current challenges and future perspectivesCássia Milena de Souza0Bárbara Tavares Bezerra1Daniel Agreda Mellon2Haroldo Cesar de Oliveira3Instituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, PR, BrazilInstituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, PR, BrazilInstituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, PR, Brazil; Programa de Pós-Graduação em Biologia Parasitária, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (Fiocruz), Rio de Janeiro, BrazilInstituto Carlos Chagas, Fundação Oswaldo Cruz (Fiocruz), Curitiba, PR, Brazil; Department of Microbiology, Immunology, and Parasitology, Discipline of Cellular Biology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil; Corresponding author at: Federal University of Sao Paulo - UNIFESP. Rua Botucatu 862 - 8º andar - CEP: 04023-062, Brazil.Fungal infections kill more than 3 million people every year. This high number reflects the significant challenges that treating these diseases worldwide presents. The current arsenal of antifungal drugs is limited and often accompanied by high toxicity to patients, elevated treatment costs, increased frequency of resistance rates, and the emergence of naturally resistant species. These treatment challenges highlight the urgency of developing new antifungal therapies, which could positively impact millions of lives each year globally. Our review offers an overview of the antifungal drugs currently available for treatment, presents the status of new antifungal drugs under clinical study, and explores ahead to future candidates that aim to help address this important global health issue.http://www.sciencedirect.com/science/article/pii/S2666517425000033Antifungal therapyAntifungal drugsAntifungal drug development |
| spellingShingle | Cássia Milena de Souza Bárbara Tavares Bezerra Daniel Agreda Mellon Haroldo Cesar de Oliveira The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives Current Research in Microbial Sciences Antifungal therapy Antifungal drugs Antifungal drug development |
| title | The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives |
| title_full | The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives |
| title_fullStr | The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives |
| title_full_unstemmed | The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives |
| title_short | The evolution of antifungal therapy: Traditional agents, current challenges and future perspectives |
| title_sort | evolution of antifungal therapy traditional agents current challenges and future perspectives |
| topic | Antifungal therapy Antifungal drugs Antifungal drug development |
| url | http://www.sciencedirect.com/science/article/pii/S2666517425000033 |
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