Life stage impact on the human skin ecosystem: lipids and the microbial community
Abstract Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between skin oxylipins and microbes on the superficial skin of pre-pubescent children (N = 36) and adults (N = 100), including pre- (N =...
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| Language: | English |
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Nature Portfolio
2025-01-01
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| Series: | npj Biofilms and Microbiomes |
| Online Access: | https://doi.org/10.1038/s41522-025-00652-7 |
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| author | Martin P. Pagac Bala Davient Luca Antonio Plado Hilbert Yuen In Lam Shi Mun Lee Aarthi Ravikrishnan Wee Ling Esther Chua Sneha Muralidharan Aishwarya Sridharan Antony S. Irudayaswamy Ramasamy Srinivas Stephen Wearne Ahmad Nazri Mohamed Naim Eliza Xin Pei Ho H. Q. Amanda Ng Junmei Samantha Kwah Eileen Png Anne K. Bendt Markus R. Wenk Federico Torta Niranjan Nagarajan John Common Yap Seng Chong Elizabeth Huiwen Tham Lynette Pei-Chi Shek Evelyn Xiu Ling Loo John Chambers Yik Weng Yew Marie Loh Thomas L. Dawson |
| author_facet | Martin P. Pagac Bala Davient Luca Antonio Plado Hilbert Yuen In Lam Shi Mun Lee Aarthi Ravikrishnan Wee Ling Esther Chua Sneha Muralidharan Aishwarya Sridharan Antony S. Irudayaswamy Ramasamy Srinivas Stephen Wearne Ahmad Nazri Mohamed Naim Eliza Xin Pei Ho H. Q. Amanda Ng Junmei Samantha Kwah Eileen Png Anne K. Bendt Markus R. Wenk Federico Torta Niranjan Nagarajan John Common Yap Seng Chong Elizabeth Huiwen Tham Lynette Pei-Chi Shek Evelyn Xiu Ling Loo John Chambers Yik Weng Yew Marie Loh Thomas L. Dawson |
| author_sort | Martin P. Pagac |
| collection | DOAJ |
| description | Abstract Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between skin oxylipins and microbes on the superficial skin of pre-pubescent children (N = 36) and adults (N = 100), including pre- (N = 25) and post-menopausal females (N = 25). Lipidomics and metagenomics revealed that Malassezia restricta positively correlated with the oxylipin 9,10-DiHOME on adult skin and negatively correlated with its precursor, 9,10-EpOME, on pre-pubescent skin. Co-culturing Malassezia with keratinocytes demonstrated a link between 9,10-DiHOME and pro-inflammatory cytokines IL-1β and IL-6 production. We also observed strong correlations between other skin oxylipins and microbial taxa, highlighting life stage differences in sebum production and microbial community composition. Our findings imply a complex host-microbe communication system mediated by lipid metabolism occurring on human skin, warranting further research into its role in skin health and disease and paving the way towards novel therapeutic targets and treatments. |
| format | Article |
| id | doaj-art-f95ace0091ff41d89aa8c8f77dbe8497 |
| institution | Kabale University |
| issn | 2055-5008 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Biofilms and Microbiomes |
| spelling | doaj-art-f95ace0091ff41d89aa8c8f77dbe84972025-01-19T12:12:16ZengNature Portfolionpj Biofilms and Microbiomes2055-50082025-01-0111111210.1038/s41522-025-00652-7Life stage impact on the human skin ecosystem: lipids and the microbial communityMartin P. Pagac0Bala Davient1Luca Antonio Plado2Hilbert Yuen In Lam3Shi Mun Lee4Aarthi Ravikrishnan5Wee Ling Esther Chua6Sneha Muralidharan7Aishwarya Sridharan8Antony S. Irudayaswamy9Ramasamy Srinivas10Stephen Wearne11Ahmad Nazri Mohamed Naim12Eliza Xin Pei Ho13H. Q. Amanda Ng14Junmei Samantha Kwah15Eileen Png16Anne K. Bendt17Markus R. Wenk18Federico Torta19Niranjan Nagarajan20John Common21Yap Seng Chong22Elizabeth Huiwen Tham23Lynette Pei-Chi Shek24Evelyn Xiu Ling Loo25John Chambers26Yik Weng Yew27Marie Loh28Thomas L. Dawson29A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of SingaporeSLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of SingaporeA*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)Genome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)SLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of SingaporeSLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of SingaporeSLING, Singapore Lipidomics Incubator, Life Sciences Institute, National University of SingaporeGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), 30 Medical DriveDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS)Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore (NUS)Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), 30 Medical DriveLee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences BuildingLee Kong Chian School of Medicine, Nanyang Technological University, Clinical Sciences BuildingGenome Institute of Singapore (GIS), Agency for Science, Technology and Research (A*STAR)A*STAR Skin Research Labs (A*SRL), Agency for Science, Technology, and Research (A*STAR) & Skin Research Institute of Singapore (SRIS)Abstract Sebaceous free fatty acids are metabolized by multiple skin microbes into bioactive lipid mediators termed oxylipins. This study investigated correlations between skin oxylipins and microbes on the superficial skin of pre-pubescent children (N = 36) and adults (N = 100), including pre- (N = 25) and post-menopausal females (N = 25). Lipidomics and metagenomics revealed that Malassezia restricta positively correlated with the oxylipin 9,10-DiHOME on adult skin and negatively correlated with its precursor, 9,10-EpOME, on pre-pubescent skin. Co-culturing Malassezia with keratinocytes demonstrated a link between 9,10-DiHOME and pro-inflammatory cytokines IL-1β and IL-6 production. We also observed strong correlations between other skin oxylipins and microbial taxa, highlighting life stage differences in sebum production and microbial community composition. Our findings imply a complex host-microbe communication system mediated by lipid metabolism occurring on human skin, warranting further research into its role in skin health and disease and paving the way towards novel therapeutic targets and treatments.https://doi.org/10.1038/s41522-025-00652-7 |
| spellingShingle | Martin P. Pagac Bala Davient Luca Antonio Plado Hilbert Yuen In Lam Shi Mun Lee Aarthi Ravikrishnan Wee Ling Esther Chua Sneha Muralidharan Aishwarya Sridharan Antony S. Irudayaswamy Ramasamy Srinivas Stephen Wearne Ahmad Nazri Mohamed Naim Eliza Xin Pei Ho H. Q. Amanda Ng Junmei Samantha Kwah Eileen Png Anne K. Bendt Markus R. Wenk Federico Torta Niranjan Nagarajan John Common Yap Seng Chong Elizabeth Huiwen Tham Lynette Pei-Chi Shek Evelyn Xiu Ling Loo John Chambers Yik Weng Yew Marie Loh Thomas L. Dawson Life stage impact on the human skin ecosystem: lipids and the microbial community npj Biofilms and Microbiomes |
| title | Life stage impact on the human skin ecosystem: lipids and the microbial community |
| title_full | Life stage impact on the human skin ecosystem: lipids and the microbial community |
| title_fullStr | Life stage impact on the human skin ecosystem: lipids and the microbial community |
| title_full_unstemmed | Life stage impact on the human skin ecosystem: lipids and the microbial community |
| title_short | Life stage impact on the human skin ecosystem: lipids and the microbial community |
| title_sort | life stage impact on the human skin ecosystem lipids and the microbial community |
| url | https://doi.org/10.1038/s41522-025-00652-7 |
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