The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome
Objective. To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. Methods. It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adu...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2020/8075482 |
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| _version_ | 1832555018716184576 |
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| author | Sonia Rouatbi Ines Ghannouchi Rim Kammoun Helmi Ben Saad |
| author_facet | Sonia Rouatbi Ines Ghannouchi Rim Kammoun Helmi Ben Saad |
| author_sort | Sonia Rouatbi |
| collection | DOAJ |
| description | Objective. To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. Methods. It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (FeNO). Results. Obesity was confirmed for the two groups with a total sample mean value of BMI = 35.06 ± 4.68 kg/m2. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93 ± 14 vs. 79 ± 12%), an abnormal DLCO (112 ± 20 vs. 93 ± 22%), and higher bronchial inflammation (18.40 ± 9.20 vs. 31.30 ± 13.60 ppb) (p<0.05). Conclusion. Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation. |
| format | Article |
| id | doaj-art-f95a67c757cd4929a1a0b8e36bf39d7d |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-f95a67c757cd4929a1a0b8e36bf39d7d2025-02-03T05:49:52ZengWileyJournal of Obesity2090-07082090-07162020-01-01202010.1155/2020/80754828075482The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea SyndromeSonia Rouatbi0Ines Ghannouchi1Rim Kammoun2Helmi Ben Saad3Laboratory of Physiology and Explorations, Faculty of Medicine Sousse, University of Sousse, Sousse, TunisiaLaboratory of Physiology and Explorations, Faculty of Medicine Sousse, University of Sousse, Sousse, TunisiaLaboratory of Physiology and Explorations, Faculty of Medicine Sousse, University of Sousse, Sousse, TunisiaLaboratory of Physiology and Explorations, Faculty of Medicine Sousse, University of Sousse, Sousse, TunisiaObjective. To analyze the ventilatory and alveolar-capillary diffusion dysfunctions in case of obesity with or without an OSAS. Methods. It is a cross-sectional study of 48 obese adults (23 OSAS and 25 controls). Anthropometric data (height, weight, and body mass index (BMI)) were collected. All adults responded to a medical questionnaire and underwent polysomnography or sleep polygraphy for apnea-hypopnea index (AHI) and percentage of desaturation measurements. The following lung function data were collected: pulmonary flows and volumes, lung transfer factor for carbon monoxide (DLCO), and fraction of exhaled nitric oxide (FeNO). Results. Obesity was confirmed for the two groups with a total sample mean value of BMI = 35.06 ± 4.68 kg/m2. A significant decrease in lung function was noted in patients with OSAS compared with controls. Indeed, when compared with the control group, the OSAS one had a severe restrictive ventilatory defect (total lung capacity: 93 ± 14 vs. 79 ± 12%), an abnormal DLCO (112 ± 20 vs. 93 ± 22%), and higher bronchial inflammation (18.40 ± 9.20 vs. 31.30 ± 13.60 ppb) (p<0.05). Conclusion. Obesity when associated with OSAS increases the severity of pulmonary function and alveolar-capillary diffusion alteration. This can be explained in part by the alveolar inflammation.http://dx.doi.org/10.1155/2020/8075482 |
| spellingShingle | Sonia Rouatbi Ines Ghannouchi Rim Kammoun Helmi Ben Saad The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome Journal of Obesity |
| title | The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome |
| title_full | The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome |
| title_fullStr | The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome |
| title_full_unstemmed | The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome |
| title_short | The Ventilatory and Diffusion Dysfunctions in Obese Patients with and without Obstructive Sleep Apnea-Hypopnea Syndrome |
| title_sort | ventilatory and diffusion dysfunctions in obese patients with and without obstructive sleep apnea hypopnea syndrome |
| url | http://dx.doi.org/10.1155/2020/8075482 |
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