Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis
The response of the adaptive immune system is usually less intense in premature neonates than term neonates. The primary objective of this study was to determine whether immunological parameters vary between preterm (PT) neonates (≥32 weeks of gestational age) and very preterm (VPT) neonates (<32...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/6740827 |
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| author | Enrique Segura-Cervantes Javier Mancilla-Ramírez Jorge González-Canudas Erika Alba René Santillán-Ballesteros Deneb Morales-Barquet Gabriela Sandoval-Plata Norma Galindo-Sevilla |
| author_facet | Enrique Segura-Cervantes Javier Mancilla-Ramírez Jorge González-Canudas Erika Alba René Santillán-Ballesteros Deneb Morales-Barquet Gabriela Sandoval-Plata Norma Galindo-Sevilla |
| author_sort | Enrique Segura-Cervantes |
| collection | DOAJ |
| description | The response of the adaptive immune system is usually less intense in premature neonates than term neonates. The primary objective of this study was to determine whether immunological parameters vary between preterm (PT) neonates (≥32 weeks of gestational age) and very preterm (VPT) neonates (<32 weeks of gestational age). A cross-sectional study was designed to prospectively follow PT and VPT neonates at risk of developing sepsis. Plasma concentrations of IFN-γ, TNF-α, IL-6, IL-4, and IL-10 were detected using flow cytometry. C-reactive protein (C-RP) and the complex SC5b-9 were detected in the plasma using commercial kits. A total of 83 patients were included. The laboratory results and clinical histories showed that 26 patients had sepsis; 14 were VPT, and 12 were PT. The levels of C-RP, SC5b-9 (innate immune response mediators), and IL-10 or IL-4 (anti-inflammatory cytokines) were elevated during sepsis in both groups. IFN-γ, TNF-α, and IL-6 (proinflammatory cytokines) were differentially elevated only in PT neonates. The VPT neonates with sepsis presented increases in C-RP, SC5b-9, and anti-inflammatory cytokines but not in proinflammatory cytokines, whereas PT neonates showed increases in all studied mediators of inflammation. |
| format | Article |
| id | doaj-art-f92f65fbe8c74db2b2abfb3ff6f813ac |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-f92f65fbe8c74db2b2abfb3ff6f813ac2025-02-03T01:30:57ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/67408276740827Inflammatory Response in Preterm and Very Preterm Newborns with SepsisEnrique Segura-Cervantes0Javier Mancilla-Ramírez1Jorge González-Canudas2Erika Alba3René Santillán-Ballesteros4Deneb Morales-Barquet5Gabriela Sandoval-Plata6Norma Galindo-Sevilla7Departamento de Epidemiología, Instituto Nacional de Perinatología, Secretaría de Salud (SSa), Montes Urales 800, Colonia Lomas de Virreyes, 11000 Mexico City, MexicoEscuela Superior de Medicina (ESM), Instituto Politécnico Nacional (IPN), Avenida Salvador Diaz Miron S/N, Esquina Plan de San Luis, Colonia Casco de Santo Tomás, Delegación Miguel Hidalgo, 11340 Mexico City, MexicoLaboratorio Silanes, Amores 1304, Colonia del Valle, 03100 Mexico City, MexicoLaboratorio Silanes, Amores 1304, Colonia del Valle, 03100 Mexico City, MexicoDepartamento de Infectología e Inmunología, Instituto Nacional de Perinatología, SSa, Montes Urales 800, Colonia Lomas de Virreyes, 11000 Mexico City, MexicoUCIREN, Instituto Nacional de Perinatología, SSa, Montes Urales 800, Colonia Lomas de Virreyes, 11000 Mexico City, MexicoLaboratorio Silanes, Amores 1304, Colonia del Valle, 03100 Mexico City, MexicoDepartamento de Infectología e Inmunología, Instituto Nacional de Perinatología, SSa, Montes Urales 800, Colonia Lomas de Virreyes, 11000 Mexico City, MexicoThe response of the adaptive immune system is usually less intense in premature neonates than term neonates. The primary objective of this study was to determine whether immunological parameters vary between preterm (PT) neonates (≥32 weeks of gestational age) and very preterm (VPT) neonates (<32 weeks of gestational age). A cross-sectional study was designed to prospectively follow PT and VPT neonates at risk of developing sepsis. Plasma concentrations of IFN-γ, TNF-α, IL-6, IL-4, and IL-10 were detected using flow cytometry. C-reactive protein (C-RP) and the complex SC5b-9 were detected in the plasma using commercial kits. A total of 83 patients were included. The laboratory results and clinical histories showed that 26 patients had sepsis; 14 were VPT, and 12 were PT. The levels of C-RP, SC5b-9 (innate immune response mediators), and IL-10 or IL-4 (anti-inflammatory cytokines) were elevated during sepsis in both groups. IFN-γ, TNF-α, and IL-6 (proinflammatory cytokines) were differentially elevated only in PT neonates. The VPT neonates with sepsis presented increases in C-RP, SC5b-9, and anti-inflammatory cytokines but not in proinflammatory cytokines, whereas PT neonates showed increases in all studied mediators of inflammation.http://dx.doi.org/10.1155/2016/6740827 |
| spellingShingle | Enrique Segura-Cervantes Javier Mancilla-Ramírez Jorge González-Canudas Erika Alba René Santillán-Ballesteros Deneb Morales-Barquet Gabriela Sandoval-Plata Norma Galindo-Sevilla Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis Mediators of Inflammation |
| title | Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis |
| title_full | Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis |
| title_fullStr | Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis |
| title_full_unstemmed | Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis |
| title_short | Inflammatory Response in Preterm and Very Preterm Newborns with Sepsis |
| title_sort | inflammatory response in preterm and very preterm newborns with sepsis |
| url | http://dx.doi.org/10.1155/2016/6740827 |
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