The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer
Abstract Background There are still gaps in the study of the miRNA and its SNPs in some diseases such as non-small cell lung cancer (NSCLC). The study aimed to provide useful information on the treatment of NSCLC by investigating the association between miR-21 and its SNPs and NSCLC susceptibility....
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BMC
2025-01-01
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| Series: | Journal of Cardiothoracic Surgery |
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| Online Access: | https://doi.org/10.1186/s13019-024-03322-5 |
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| _version_ | 1832585397971976192 |
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| author | Miao Zhang Ming Zhang Ruixue Han Xin Yu Zhaolu Song |
| author_facet | Miao Zhang Ming Zhang Ruixue Han Xin Yu Zhaolu Song |
| author_sort | Miao Zhang |
| collection | DOAJ |
| description | Abstract Background There are still gaps in the study of the miRNA and its SNPs in some diseases such as non-small cell lung cancer (NSCLC). The study aimed to provide useful information on the treatment of NSCLC by investigating the association between miR-21 and its SNPs and NSCLC susceptibility. Methods The serum of NSCLC patients (n = 205) and cancer-free controls (n = 217) were collected in this study for RNA extraction. The qRT-PCR was used to evaluate the expression of miR-21 and Taqman qPCR was used for genotyping and quantifying miR-21 SNPs (rs1292037, rs6504593). The association of the expression of miR-21, the miR-21 SNPs and their interactions with the susceptibility of NSCLC patients were analysed using logistic regression analysis in this study. Results This study showed that the overexpression of miR-21 was related to NSCLC. The C allele and CC genotypes of rs1292037 and rs6504593 were associated with the increased risk of NSCLC susceptibility. Moreover, the interactions of rs1292037 and rs6504593 were also a risk factor for NSCLC. The CC genotypes of rs1292037 and rs6504593 were associated with the increase of miR-21 expression. Conclusion The overexpression of miR-21, the miR-21 SNPs rs1292037 and rs6504593 and their interactions were associated with NSCLC susceptibility. MiR-21 and its SNPs have potential for being targets in the therapy of NSCLC. This study provided important information for the treatment of NSCLC. |
| format | Article |
| id | doaj-art-f913c04df3f846e3ac79de4cf7cdc36c |
| institution | Kabale University |
| issn | 1749-8090 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Cardiothoracic Surgery |
| spelling | doaj-art-f913c04df3f846e3ac79de4cf7cdc36c2025-01-26T12:51:57ZengBMCJournal of Cardiothoracic Surgery1749-80902025-01-012011810.1186/s13019-024-03322-5The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancerMiao Zhang0Ming Zhang1Ruixue Han2Xin Yu3Zhaolu Song4Department of Respiratory, Jiaozhou Central Hospital of QingdaoDepartment of Clinical Medicine, Anhui Medical CollegeDepartment of Oncology, Yuhuan Second People’s HospitalDepartment of Respiratory Medicine, Traditional Chinese Medical Hospital of ZhujiDepartment of Urology Surgery, Jiaozhou Central Hospital of QingdaoAbstract Background There are still gaps in the study of the miRNA and its SNPs in some diseases such as non-small cell lung cancer (NSCLC). The study aimed to provide useful information on the treatment of NSCLC by investigating the association between miR-21 and its SNPs and NSCLC susceptibility. Methods The serum of NSCLC patients (n = 205) and cancer-free controls (n = 217) were collected in this study for RNA extraction. The qRT-PCR was used to evaluate the expression of miR-21 and Taqman qPCR was used for genotyping and quantifying miR-21 SNPs (rs1292037, rs6504593). The association of the expression of miR-21, the miR-21 SNPs and their interactions with the susceptibility of NSCLC patients were analysed using logistic regression analysis in this study. Results This study showed that the overexpression of miR-21 was related to NSCLC. The C allele and CC genotypes of rs1292037 and rs6504593 were associated with the increased risk of NSCLC susceptibility. Moreover, the interactions of rs1292037 and rs6504593 were also a risk factor for NSCLC. The CC genotypes of rs1292037 and rs6504593 were associated with the increase of miR-21 expression. Conclusion The overexpression of miR-21, the miR-21 SNPs rs1292037 and rs6504593 and their interactions were associated with NSCLC susceptibility. MiR-21 and its SNPs have potential for being targets in the therapy of NSCLC. This study provided important information for the treatment of NSCLC.https://doi.org/10.1186/s13019-024-03322-5miR-21NSCLCPolymorphismsSNP-SNP interaction |
| spellingShingle | Miao Zhang Ming Zhang Ruixue Han Xin Yu Zhaolu Song The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer Journal of Cardiothoracic Surgery miR-21 NSCLC Polymorphisms SNP-SNP interaction |
| title | The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer |
| title_full | The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer |
| title_fullStr | The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer |
| title_full_unstemmed | The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer |
| title_short | The correlation between miR-21 single nucleotide polymorphisms and the susceptibility of non-small cell lung cancer |
| title_sort | correlation between mir 21 single nucleotide polymorphisms and the susceptibility of non small cell lung cancer |
| topic | miR-21 NSCLC Polymorphisms SNP-SNP interaction |
| url | https://doi.org/10.1186/s13019-024-03322-5 |
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