Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension
Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2011-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.4061/2011/281240 |
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| _version_ | 1832559460345708544 |
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| author | Carmine Savoia Lidia Sada Luigi Zezza Lorenzo Pucci Francesco Maria Lauri Alberto Befani Alessandro Alonzo Massimo Volpe |
| author_facet | Carmine Savoia Lidia Sada Luigi Zezza Lorenzo Pucci Francesco Maria Lauri Alberto Befani Alessandro Alonzo Massimo Volpe |
| author_sort | Carmine Savoia |
| collection | DOAJ |
| description | Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases. |
| format | Article |
| id | doaj-art-f9121b5446d94390a11cab0a6965386a |
| institution | Kabale University |
| issn | 2090-0392 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-f9121b5446d94390a11cab0a6965386a2025-02-03T01:30:00ZengWileyInternational Journal of Hypertension2090-03922011-01-01201110.4061/2011/281240281240Vascular Inflammation and Endothelial Dysfunction in Experimental HypertensionCarmine Savoia0Lidia Sada1Luigi Zezza2Lorenzo Pucci3Francesco Maria Lauri4Alberto Befani5Alessandro Alonzo6Massimo Volpe7Cardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyCardiology Unit, Clinical and Molecular Medicine Department, Sant'Andrea Hospital, Sapienza University of Rome, Via di Grottarossa 1037/1039, 00189 Rome, ItalyEssential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.http://dx.doi.org/10.4061/2011/281240 |
| spellingShingle | Carmine Savoia Lidia Sada Luigi Zezza Lorenzo Pucci Francesco Maria Lauri Alberto Befani Alessandro Alonzo Massimo Volpe Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension International Journal of Hypertension |
| title | Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension |
| title_full | Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension |
| title_fullStr | Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension |
| title_full_unstemmed | Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension |
| title_short | Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension |
| title_sort | vascular inflammation and endothelial dysfunction in experimental hypertension |
| url | http://dx.doi.org/10.4061/2011/281240 |
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