Acute kidney injury in children with cancer admitted in an intensive care unit
Objective: Evaluating the association between acute kidney injury and death in critically ill children with oncological diseases admitted in an intensive care unit (ICU). Material and Methods: Unicentric cohort study, evolving children with cancer admitted in th...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações Ltda.
2022-10-01
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| Series: | Brazilian Journal of Oncology |
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| Online Access: | https://www.brazilianjournalofoncology.com.br/details/201/en-US/acute-kidney-injury-in-children-with-cancer-admitted-in-an-intensive-care-unit |
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| author | Jáder Pereira Almeida Gabriela Caus Fernandes Luiz Scheilla Torres De-Oliveira Larissa Nicolini De-Santa Giovanna Soldatelli Borsato Paulo Ramos David João |
| author_facet | Jáder Pereira Almeida Gabriela Caus Fernandes Luiz Scheilla Torres De-Oliveira Larissa Nicolini De-Santa Giovanna Soldatelli Borsato Paulo Ramos David João |
| author_sort | Jáder Pereira Almeida |
| collection | DOAJ |
| description | Objective: Evaluating the association between acute kidney injury and death in critically ill children with oncological diseases admitted in an intensive care unit (ICU).
Material and Methods: Unicentric cohort study, evolving children with cancer admitted in the ICU of a pediatrics referral hospital. The patients were divided according to the presence or absence of acute kidney injury. Patients with a history of urogenital disease, nephrectomy or chronic kidney disease were excluded. The acute kidney injury was defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification. The main outcome was death.
Results: The sample was composed of 84 patients, in which 46.4% were diagnosed with hematologic neoplasm, 29.8% evolved with febrile neutropenia, 11.9% had a history of bone marrow transplant, and 27.3% deceased. Acute kidney injury occurred in 51.2% of the sample, 53.6% used furosemide, 38% showed fluid overload, and 8.3% had renal replacement therapy. The main variables related to kidney dysfunction were admission due to hemodynamic shock, pediatric risk of mortality score 2 ≥5%, bone marrow transplant, volume overload and multiple organ dysfunction syndrome. More advanced stages of acute kidney injury were associated with renal replacement therapy (p<0.001), longer stay in the ICU (p=0.006), and death (p=0.003).
Conclusion: Children with cancer showed many risk factors of acute kidney injury, and this complication is associated with higher death rate. |
| format | Article |
| id | doaj-art-f90e6d1c8e9648ad836e7a5a46b044d2 |
| institution | DOAJ |
| issn | 2526-8732 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações Ltda. |
| record_format | Article |
| series | Brazilian Journal of Oncology |
| spelling | doaj-art-f90e6d1c8e9648ad836e7a5a46b044d22025-08-20T03:20:09ZengThieme Revinter Publicações Ltda.Brazilian Journal of Oncology2526-87322022-10-01180010.5935/2526-8732.20220291Acute kidney injury in children with cancer admitted in an intensive care unitJáder Pereira Almeida0https://orcid.org/0000-0002-1374-4178Gabriela Caus Fernandes Luiz1Scheilla Torres De-Oliveira2Larissa Nicolini De-Santa3Giovanna Soldatelli Borsato4Paulo Ramos David João5Santa Casa de Belo Horizonte, Terapia Intensiva Pediátrica - Belo Horizonte - Minas Gerais - BrazilHospital Infantil Pequeno Príncipe, Oncologia Pediátrica - Curitiba - Paraná - BrazilSanta Casa de Belo Horizonte, Oncologia Pediátrica - Belo Horizonte - Minas Gerais - BrazilUniversidade Positivo, Faculdade de Medicina - Curitiba - Paraná - BrazilPontifícia Universidade Católica do Paraná, Faculdade de Medicina - Curitiba - Paraná - BrazilHospital Infantil Pequeno Príncipe, Terapia Intensiva Pediátrica - Curitiba - Paraná - BrazilObjective: Evaluating the association between acute kidney injury and death in critically ill children with oncological diseases admitted in an intensive care unit (ICU). Material and Methods: Unicentric cohort study, evolving children with cancer admitted in the ICU of a pediatrics referral hospital. The patients were divided according to the presence or absence of acute kidney injury. Patients with a history of urogenital disease, nephrectomy or chronic kidney disease were excluded. The acute kidney injury was defined by the Kidney Disease Improving Global Outcomes (KDIGO) classification. The main outcome was death. Results: The sample was composed of 84 patients, in which 46.4% were diagnosed with hematologic neoplasm, 29.8% evolved with febrile neutropenia, 11.9% had a history of bone marrow transplant, and 27.3% deceased. Acute kidney injury occurred in 51.2% of the sample, 53.6% used furosemide, 38% showed fluid overload, and 8.3% had renal replacement therapy. The main variables related to kidney dysfunction were admission due to hemodynamic shock, pediatric risk of mortality score 2 ≥5%, bone marrow transplant, volume overload and multiple organ dysfunction syndrome. More advanced stages of acute kidney injury were associated with renal replacement therapy (p<0.001), longer stay in the ICU (p=0.006), and death (p=0.003). Conclusion: Children with cancer showed many risk factors of acute kidney injury, and this complication is associated with higher death rate.https://www.brazilianjournalofoncology.com.br/details/201/en-US/acute-kidney-injury-in-children-with-cancer-admitted-in-an-intensive-care-unitacute kidney injurypediatric intensive care unitsmedical oncologychildmultiple organ failure |
| spellingShingle | Jáder Pereira Almeida Gabriela Caus Fernandes Luiz Scheilla Torres De-Oliveira Larissa Nicolini De-Santa Giovanna Soldatelli Borsato Paulo Ramos David João Acute kidney injury in children with cancer admitted in an intensive care unit Brazilian Journal of Oncology acute kidney injury pediatric intensive care units medical oncology child multiple organ failure |
| title | Acute kidney injury in children with cancer admitted in an intensive care unit |
| title_full | Acute kidney injury in children with cancer admitted in an intensive care unit |
| title_fullStr | Acute kidney injury in children with cancer admitted in an intensive care unit |
| title_full_unstemmed | Acute kidney injury in children with cancer admitted in an intensive care unit |
| title_short | Acute kidney injury in children with cancer admitted in an intensive care unit |
| title_sort | acute kidney injury in children with cancer admitted in an intensive care unit |
| topic | acute kidney injury pediatric intensive care units medical oncology child multiple organ failure |
| url | https://www.brazilianjournalofoncology.com.br/details/201/en-US/acute-kidney-injury-in-children-with-cancer-admitted-in-an-intensive-care-unit |
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