Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review
Changes in dispersion of ventricular repolarization is a salient electrophysiological feature of acute myocardial ischemia and linked to life-threatening arrhythmias. In 9 studies, we applied Frank vectorcardiography not only for noninvasive monitoring of cardiac electrophysiology during acute ische...
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Elsevier
2025-05-01
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| Series: | Heart Rhythm O2 |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666501825000571 |
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| author | Lennart Bergfeldt, MD, PhD Lennart Gransberg, MSc, PhD Gunilla Lundahl, MSc |
| author_facet | Lennart Bergfeldt, MD, PhD Lennart Gransberg, MSc, PhD Gunilla Lundahl, MSc |
| author_sort | Lennart Bergfeldt, MD, PhD |
| collection | DOAJ |
| description | Changes in dispersion of ventricular repolarization is a salient electrophysiological feature of acute myocardial ischemia and linked to life-threatening arrhythmias. In 9 studies, we applied Frank vectorcardiography not only for noninvasive monitoring of cardiac electrophysiology during acute ischemia induced during percutaneous coronary interventions, during clinical myocardial infarction, and in an occlusion-reperfusion pig model, but also for prognostic purposes after coronary events. Myocardial ischemia was in humans and pigs associated with significant changes in the ST segment, Tamplitude, Tarea, ventricular gradient, and T vector loop morphology. In the pig model, a link between dispersion changes and the occurrence and suppression (by spinal cord stimulation) of ventricular arrhythmias was found. Prognostically, after recent acute coronary events, the spatial peak and mean QRS-T angles were superior. In summary, vectorcardiography-based parameters were validated as reflecting changes in repolarization dispersion during myocardial ischemia in humans and pigs, and in pigs linked to the occurrence and suppression of ventricular arrhythmias. |
| format | Article |
| id | doaj-art-f9078f2f714e4fcdb2c5d216f4be0641 |
| institution | OA Journals |
| issn | 2666-5018 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heart Rhythm O2 |
| spelling | doaj-art-f9078f2f714e4fcdb2c5d216f4be06412025-08-20T02:33:18ZengElsevierHeart Rhythm O22666-50182025-05-016570971910.1016/j.hroo.2025.02.005Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A reviewLennart Bergfeldt, MD, PhD0Lennart Gransberg, MSc, PhD1Gunilla Lundahl, MSc2Address reprint requests and correspondence: Dr Lennart Bergfeldt, Wallenberg Laboratory, Bruna Stråket 16, Sahlgrenska University Hospital, S-413 45 Gothenburg, Sweden.; Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, SwedenChanges in dispersion of ventricular repolarization is a salient electrophysiological feature of acute myocardial ischemia and linked to life-threatening arrhythmias. In 9 studies, we applied Frank vectorcardiography not only for noninvasive monitoring of cardiac electrophysiology during acute ischemia induced during percutaneous coronary interventions, during clinical myocardial infarction, and in an occlusion-reperfusion pig model, but also for prognostic purposes after coronary events. Myocardial ischemia was in humans and pigs associated with significant changes in the ST segment, Tamplitude, Tarea, ventricular gradient, and T vector loop morphology. In the pig model, a link between dispersion changes and the occurrence and suppression (by spinal cord stimulation) of ventricular arrhythmias was found. Prognostically, after recent acute coronary events, the spatial peak and mean QRS-T angles were superior. In summary, vectorcardiography-based parameters were validated as reflecting changes in repolarization dispersion during myocardial ischemia in humans and pigs, and in pigs linked to the occurrence and suppression of ventricular arrhythmias.http://www.sciencedirect.com/science/article/pii/S2666501825000571Myocardial ischemiaDispersionArrhythmogenesisArrhythmia suppressionVectorcardiographySpinal cord stimulation |
| spellingShingle | Lennart Bergfeldt, MD, PhD Lennart Gransberg, MSc, PhD Gunilla Lundahl, MSc Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review Heart Rhythm O2 Myocardial ischemia Dispersion Arrhythmogenesis Arrhythmia suppression Vectorcardiography Spinal cord stimulation |
| title | Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review |
| title_full | Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review |
| title_fullStr | Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review |
| title_full_unstemmed | Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review |
| title_short | Ischemia induced repolarization dispersion changes and ventricular arrhythmia: Validation of Frank vectorcardiography parameters: A review |
| title_sort | ischemia induced repolarization dispersion changes and ventricular arrhythmia validation of frank vectorcardiography parameters a review |
| topic | Myocardial ischemia Dispersion Arrhythmogenesis Arrhythmia suppression Vectorcardiography Spinal cord stimulation |
| url | http://www.sciencedirect.com/science/article/pii/S2666501825000571 |
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