Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis

Exploratory profiling of metabolites in cerebrospinal fluid using a commercially available targeted LC-MS based metabolomics kit to discriminate leptomeningeal metastasis

Abstract Background Leptomeningeal metastasis (LM) is a devastating complication of cancer that is difficult to treat. Thus, early diagnosis is essential for LM patients. However, cerebrospinal fluid (CSF) cytology has low sensitivity, and imaging approaches are ineffective. We explored targeted CSF...

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Main Authors: Soojin Jang, Ho-Shin Gwak, Kyue-Yim Lee, Jun Hwa Lee, Kyung-Hee Kim, Jong Heon Kim, Jong Bae Park, Sang Hoon Shin, Heon Yoo, Yun-Sik Dho, Kyu-Chang Wang, Byong Chul Yoo
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Cancer & Metabolism
Subjects:
Cerebrospinal fluid
Metabolome
Leptomeningeal metastasis
Profile
Diagnosis
Online Access:https://doi.org/10.1186/s40170-024-00367-x
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