Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin
While it is well established that stroke and cerebral hypoperfusion are risk factors for Alzheimer's disease (AD), the molecular link between ischemia/hypoxia and amyloid precursor protein (APP) processing has only been recently established. Here we review the role of the release of reactive ox...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2009.93 |
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| _version_ | 1832561744902356992 |
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| author | Michela Guglielmotto Elena Tamagno Oliviero Danni |
| author_facet | Michela Guglielmotto Elena Tamagno Oliviero Danni |
| author_sort | Michela Guglielmotto |
| collection | DOAJ |
| description | While it is well established that stroke and cerebral hypoperfusion are risk factors for Alzheimer's disease (AD), the molecular link between ischemia/hypoxia and amyloid precursor protein (APP) processing has only been recently established. Here we review the role of the release of reactive oxygen species (ROS) by the mitochondrial electron chain in response to hypoxia, providing evidence that hypoxia fosters the amyloidogenic APP processing through a biphasic mechanism that up-regulates β-secretase activity, which involves an early release of ROS and an activation of HIF-1α. |
| format | Article |
| id | doaj-art-f8f2e8039e444970ad2daee6e006e664 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-f8f2e8039e444970ad2daee6e006e6642025-02-03T01:24:23ZengWileyThe Scientific World Journal1537-744X2009-01-01978179110.1100/tsw.2009.93Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same CoinMichela Guglielmotto0Elena Tamagno1Oliviero Danni2Department of Experimental Medicine and Oncology, University of Torino, ItalyDepartment of Experimental Medicine and Oncology, University of Torino, ItalyDepartment of Experimental Medicine and Oncology, University of Torino, ItalyWhile it is well established that stroke and cerebral hypoperfusion are risk factors for Alzheimer's disease (AD), the molecular link between ischemia/hypoxia and amyloid precursor protein (APP) processing has only been recently established. Here we review the role of the release of reactive oxygen species (ROS) by the mitochondrial electron chain in response to hypoxia, providing evidence that hypoxia fosters the amyloidogenic APP processing through a biphasic mechanism that up-regulates β-secretase activity, which involves an early release of ROS and an activation of HIF-1α.http://dx.doi.org/10.1100/tsw.2009.93 |
| spellingShingle | Michela Guglielmotto Elena Tamagno Oliviero Danni Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin The Scientific World Journal |
| title | Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin |
| title_full | Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin |
| title_fullStr | Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin |
| title_full_unstemmed | Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin |
| title_short | Oxidative Stress and Hypoxia Contribute to Alzheimer's Disease Pathogenesis: Two Sides of the Same Coin |
| title_sort | oxidative stress and hypoxia contribute to alzheimer s disease pathogenesis two sides of the same coin |
| url | http://dx.doi.org/10.1100/tsw.2009.93 |
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