Implementation Nutrigenomic of Vitamin D in Periodontitis
Background: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on the human genome, either directly or indirectly, can change the expression and structure of genes. One of the micronutrients associated with periodontitis is vitamin D. Vitamin D has an i...
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Universitas Airlangga
2022-07-01
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| Series: | Journal of Vocational Health Studies |
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| Online Access: | https://e-journal.unair.ac.id/JVHS/article/view/27049 |
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| author | Hervina Hervina I Dewa Made Sukrama I Made Jawi |
| author_facet | Hervina Hervina I Dewa Made Sukrama I Made Jawi |
| author_sort | Hervina Hervina |
| collection | DOAJ |
| description | Background: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on the human genome, either directly or indirectly, can change the expression and structure of genes. One of the micronutrients associated with periodontitis is vitamin D. Vitamin D has an important role in bone and calcium metabolism and regulates serum calcium and phosphate concentrations at normal limits. Purpose: To discuss the nutritional vitamin D as an essential micronutrient in preventing and accelerating healing in periodontitis. Review: Searched two databases from article publication to April 2021, resulting in a total of 66 hits, from which seven relevant articles were selected. VDR signaling can build transcription of genes encoding proactive cytokines, bypassing the cyclo-oxygenase-2 (COX-2) and prostaglandin pathway, and can inhibit matrix metalloproteinase production. The protective mechanism of vitamin D against periodontitis occurs through two biological pathways, namely anti-microbial and anti-inflammatory pathways. The anti-microbial effect of vitamin D results from the binding of 1,25(OH)2D3 with VDR which then induces cAMP, b-def-2 and b-def-3 peptides by macrophages, monocytes, gingival epithelium and periodontal ligament epithelium. The anti-inflammatory effect occurs through decreased production of proinflammatory cytokines. Conclusion: All the signaling effects of VDR can reduce bacteria induced in the inflammatory cytokines so that personalized vitamin D supplementation with an adjusted dose as needed can be used in preventing periodontitis or accelerating the healing of periodontitis. |
| format | Article |
| id | doaj-art-f8e455ff3b15412caf8001506d9ae948 |
| institution | Kabale University |
| issn | 2580-7161 2580-717X |
| language | English |
| publishDate | 2022-07-01 |
| publisher | Universitas Airlangga |
| record_format | Article |
| series | Journal of Vocational Health Studies |
| spelling | doaj-art-f8e455ff3b15412caf8001506d9ae9482025-02-02T22:12:21ZengUniversitas AirlanggaJournal of Vocational Health Studies2580-71612580-717X2022-07-0161737710.20473/jvhs.V6.I1.2022.73-77Implementation Nutrigenomic of Vitamin D in PeriodontitisHervina Hervina0https://orcid.org/0000-0003-2439-5513 I Dewa Made Sukrama1https://orcid.org/0000-0002-0729-9573 I Made Jawi2https://orcid.org/0000-0003-3212-262X Department of Periodontics, Faculty of Dentistry, Mahasaraswati University, IndonesiaDepartment of Clinical Microbiology, Faculty of Medicine, Udayana University, IndonesiaDepartment of Pharmacology, Faculty of Medicine, Udayana University, IndonesiaBackground: Nutrition is a significant risk factor for the incidence of periodontal disease. Nutrients acting on the human genome, either directly or indirectly, can change the expression and structure of genes. One of the micronutrients associated with periodontitis is vitamin D. Vitamin D has an important role in bone and calcium metabolism and regulates serum calcium and phosphate concentrations at normal limits. Purpose: To discuss the nutritional vitamin D as an essential micronutrient in preventing and accelerating healing in periodontitis. Review: Searched two databases from article publication to April 2021, resulting in a total of 66 hits, from which seven relevant articles were selected. VDR signaling can build transcription of genes encoding proactive cytokines, bypassing the cyclo-oxygenase-2 (COX-2) and prostaglandin pathway, and can inhibit matrix metalloproteinase production. The protective mechanism of vitamin D against periodontitis occurs through two biological pathways, namely anti-microbial and anti-inflammatory pathways. The anti-microbial effect of vitamin D results from the binding of 1,25(OH)2D3 with VDR which then induces cAMP, b-def-2 and b-def-3 peptides by macrophages, monocytes, gingival epithelium and periodontal ligament epithelium. The anti-inflammatory effect occurs through decreased production of proinflammatory cytokines. Conclusion: All the signaling effects of VDR can reduce bacteria induced in the inflammatory cytokines so that personalized vitamin D supplementation with an adjusted dose as needed can be used in preventing periodontitis or accelerating the healing of periodontitis.https://e-journal.unair.ac.id/JVHS/article/view/27049nutrigenomikperiodontitisvitamin d |
| spellingShingle | Hervina Hervina I Dewa Made Sukrama I Made Jawi Implementation Nutrigenomic of Vitamin D in Periodontitis Journal of Vocational Health Studies nutrigenomik periodontitis vitamin d |
| title | Implementation Nutrigenomic of Vitamin D in Periodontitis |
| title_full | Implementation Nutrigenomic of Vitamin D in Periodontitis |
| title_fullStr | Implementation Nutrigenomic of Vitamin D in Periodontitis |
| title_full_unstemmed | Implementation Nutrigenomic of Vitamin D in Periodontitis |
| title_short | Implementation Nutrigenomic of Vitamin D in Periodontitis |
| title_sort | implementation nutrigenomic of vitamin d in periodontitis |
| topic | nutrigenomik periodontitis vitamin d |
| url | https://e-journal.unair.ac.id/JVHS/article/view/27049 |
| work_keys_str_mv | AT hervinahervina implementationnutrigenomicofvitamindinperiodontitis AT idewamadesukrama implementationnutrigenomicofvitamindinperiodontitis AT imadejawi implementationnutrigenomicofvitamindinperiodontitis |