Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model

Loss of TRPV4 is insufficient to promote repair in a spinal cord injury contusion model

Abstract Microglia, the primary phagocytes activated after spinal cord injury (SCI), play a key role in containing the lesion and protecting the glial scar from infiltrating immune cells. Although these responses are initially protective, excessive microglial proliferation and sustained pro-inflamma...

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Bibliographic Details
Main Authors: Melanie Mertens, Sofie Kessels, Naomi Veeningen, Elle E. M. Scheijen, Femke Mussen, Amber Delbroek, Jana Van Broeckhoven, Yeranddy A. Alpizar, Bert Brône
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Spinal cord injury
Phagocytes
Transient receptor potential vanilloid 4
Contusion model
Bone marrow transplantation
Online Access:https://doi.org/10.1038/s41598-025-12372-1
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