Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis
Objective: Tumor budding (TB) has shown promising results as a prognostic marker in several cancers such as colorectal carcinoma, breast carcinoma etc. It has been co-related to aggressiveness of the tumor and can also predict the metastasis to the lymph nodes. This systematic review evaluates the p...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-07-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426824000691 |
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| author | Gouri S. Panchannavar Punnya V. Angadi |
| author_facet | Gouri S. Panchannavar Punnya V. Angadi |
| author_sort | Gouri S. Panchannavar |
| collection | DOAJ |
| description | Objective: Tumor budding (TB) has shown promising results as a prognostic marker in several cancers such as colorectal carcinoma, breast carcinoma etc. It has been co-related to aggressiveness of the tumor and can also predict the metastasis to the lymph nodes. This systematic review evaluates the prognostic potential of TB in predicting lymph node metastasis (LNM) in OSCC. Data sources: Systematic search was carried out in the electronic data-bases i.e. PubMed, Cochrane and Google scholar for original studies related to TB in OSCC. The assessment of risk bias was done using QUIPS tool. Meta-analysis was done using STATA software. Results: A total of 25 articles were included. A significant association was noted for overall survival and prognosis but not for TB LNM in OSCC. Meta-analysis revealed a pooled estimate i.e odds ratio of 2.10 (CI - 0.00 - 4.20) for TB and LNM while for overall survival, it was 2.29 (CI-1.81–2.76). Conclusion: Tumor budding though is strongly associated with LNM in OSCC did not show significant relationship in this systematic review but demonstrated a higher correlation with overall survival. It highlights that TB is an important parameter for prognosis of oral cancer but its potential in prediction of LNM needs further validation. |
| format | Article |
| id | doaj-art-f8d79fcfbf8e4a7b8d04d7acf280fb55 |
| institution | Kabale University |
| issn | 2212-4268 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-f8d79fcfbf8e4a7b8d04d7acf280fb552025-01-24T04:45:03ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682024-07-01144362369Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-AnalysisGouri S. Panchannavar0Punnya V. Angadi1Department of Oral Pathology and Microbiology, R V Dental College, Bengaluru, IndiaDepartment of Oral Pathology and Microbiology, VK Institute of Dental Sciences, KLE Academy of Higher Education and Research (KAHER), Belgaum, 590010, Karnataka, India; Corresponding author. Department of Oral Pathology and Medicine, KLE VK Institute of Dental Sciences and Hospital, KLE Academy of Higher Education and Research(KAHER), Belgaum, 590010, Karnataka, India.Objective: Tumor budding (TB) has shown promising results as a prognostic marker in several cancers such as colorectal carcinoma, breast carcinoma etc. It has been co-related to aggressiveness of the tumor and can also predict the metastasis to the lymph nodes. This systematic review evaluates the prognostic potential of TB in predicting lymph node metastasis (LNM) in OSCC. Data sources: Systematic search was carried out in the electronic data-bases i.e. PubMed, Cochrane and Google scholar for original studies related to TB in OSCC. The assessment of risk bias was done using QUIPS tool. Meta-analysis was done using STATA software. Results: A total of 25 articles were included. A significant association was noted for overall survival and prognosis but not for TB LNM in OSCC. Meta-analysis revealed a pooled estimate i.e odds ratio of 2.10 (CI - 0.00 - 4.20) for TB and LNM while for overall survival, it was 2.29 (CI-1.81–2.76). Conclusion: Tumor budding though is strongly associated with LNM in OSCC did not show significant relationship in this systematic review but demonstrated a higher correlation with overall survival. It highlights that TB is an important parameter for prognosis of oral cancer but its potential in prediction of LNM needs further validation.http://www.sciencedirect.com/science/article/pii/S2212426824000691Tumor buddingHistopathologic markerOral squamous cell carcinomaLymph node metastasesPrognosisAssessment |
| spellingShingle | Gouri S. Panchannavar Punnya V. Angadi Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis Journal of Oral Biology and Craniofacial Research Tumor budding Histopathologic marker Oral squamous cell carcinoma Lymph node metastases Prognosis Assessment |
| title | Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis |
| title_full | Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis |
| title_fullStr | Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis |
| title_full_unstemmed | Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis |
| title_short | Tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in Oral Squamous Cell Carcinoma – Systematic Review Update and Meta-Analysis |
| title_sort | tumor budding is a prognostic marker for overall survival and not for lymph node metastasis in oral squamous cell carcinoma systematic review update and meta analysis |
| topic | Tumor budding Histopathologic marker Oral squamous cell carcinoma Lymph node metastases Prognosis Assessment |
| url | http://www.sciencedirect.com/science/article/pii/S2212426824000691 |
| work_keys_str_mv | AT gourispanchannavar tumorbuddingisaprognosticmarkerforoverallsurvivalandnotforlymphnodemetastasisinoralsquamouscellcarcinomasystematicreviewupdateandmetaanalysis AT punnyavangadi tumorbuddingisaprognosticmarkerforoverallsurvivalandnotforlymphnodemetastasisinoralsquamouscellcarcinomasystematicreviewupdateandmetaanalysis |