Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients
Background. Orthotopic lung transplantation is now widely performed in patients with advanced lung disease. Patients with moderate or severe ventricular systolic dysfunction are typically excluded from lung transplantation; however, there is a paucity of data regarding the prognostic significance of...
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| Language: | English |
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Wiley
2013-01-01
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| Series: | Journal of Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2013/391620 |
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| author | Ajay Yadlapati Joseph P. Lynch Rajan Saggar David Ross John A. Belperio Stephen Weigt Abbas Ardehali Tristan Grogan Eric H. Yang Jamil Aboulhosn |
| author_facet | Ajay Yadlapati Joseph P. Lynch Rajan Saggar David Ross John A. Belperio Stephen Weigt Abbas Ardehali Tristan Grogan Eric H. Yang Jamil Aboulhosn |
| author_sort | Ajay Yadlapati |
| collection | DOAJ |
| description | Background. Orthotopic lung transplantation is now widely performed in patients with advanced lung disease. Patients with moderate or severe ventricular systolic dysfunction are typically excluded from lung transplantation; however, there is a paucity of data regarding the prognostic significance of abnormal left ventricular diastolic function and elevated pretransplant pulmonary pressures. Methods. We reviewed the characteristics of 111 patients who underwent bilateral and unilateral lung transplants from 200 to 2009 in order to evaluate the prognostic significance of preoperative markers of diastolic function, including invasively measured pulmonary capillary wedge pressure (PCWP) and echocardiographic variables of diastolic dysfunction including mitral A>E and A′>E′. Results. Out of 111 patients, 62 were male (56%) and average age was 54.0 ± 10.5 years. Traditional echocardiographic Doppler variables of abnormal diastolic function, including A′>E′ and A>E, did not predict adverse events (P=0.49). Mildly elevated pretransplant PCWP (16–20 mmHg) and moderately/severely elevated PCWP (>20 mmHg) were not associated with adverse clinical events after transplant (P=0.30). Additionally, all clinical endpoints did not show any statistical significance between the two groups. Conclusions. Pre-lung transplant invasive and echocardiographic findings of elevated pulmonary pressures and abnormal left ventricular diastolic function are not predictive of adverse posttransplant clinical events. |
| format | Article |
| id | doaj-art-f8d0f788ef684435be9b5313d598a566 |
| institution | Kabale University |
| issn | 2090-0007 2090-0015 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Transplantation |
| spelling | doaj-art-f8d0f788ef684435be9b5313d598a5662025-02-03T05:54:10ZengWileyJournal of Transplantation2090-00072090-00152013-01-01201310.1155/2013/391620391620Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant RecipientsAjay Yadlapati0Joseph P. Lynch1Rajan Saggar2David Ross3John A. Belperio4Stephen Weigt5Abbas Ardehali6Tristan Grogan7Eric H. Yang8Jamil Aboulhosn9Department of Cardiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pulmonary & Critical Care, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pulmonary & Critical Care, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pulmonary & Critical Care, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pulmonary & Critical Care, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Pulmonary & Critical Care, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Thoracic Surgery and Transplant Surgery, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Medicine Statistics Core, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Cardiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USADepartment of Cardiology, UCLA Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USABackground. Orthotopic lung transplantation is now widely performed in patients with advanced lung disease. Patients with moderate or severe ventricular systolic dysfunction are typically excluded from lung transplantation; however, there is a paucity of data regarding the prognostic significance of abnormal left ventricular diastolic function and elevated pretransplant pulmonary pressures. Methods. We reviewed the characteristics of 111 patients who underwent bilateral and unilateral lung transplants from 200 to 2009 in order to evaluate the prognostic significance of preoperative markers of diastolic function, including invasively measured pulmonary capillary wedge pressure (PCWP) and echocardiographic variables of diastolic dysfunction including mitral A>E and A′>E′. Results. Out of 111 patients, 62 were male (56%) and average age was 54.0 ± 10.5 years. Traditional echocardiographic Doppler variables of abnormal diastolic function, including A′>E′ and A>E, did not predict adverse events (P=0.49). Mildly elevated pretransplant PCWP (16–20 mmHg) and moderately/severely elevated PCWP (>20 mmHg) were not associated with adverse clinical events after transplant (P=0.30). Additionally, all clinical endpoints did not show any statistical significance between the two groups. Conclusions. Pre-lung transplant invasive and echocardiographic findings of elevated pulmonary pressures and abnormal left ventricular diastolic function are not predictive of adverse posttransplant clinical events.http://dx.doi.org/10.1155/2013/391620 |
| spellingShingle | Ajay Yadlapati Joseph P. Lynch Rajan Saggar David Ross John A. Belperio Stephen Weigt Abbas Ardehali Tristan Grogan Eric H. Yang Jamil Aboulhosn Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients Journal of Transplantation |
| title | Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients |
| title_full | Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients |
| title_fullStr | Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients |
| title_full_unstemmed | Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients |
| title_short | Preoperative Cardiac Variables of Diastolic Dysfunction and Clinical Outcomes in Lung Transplant Recipients |
| title_sort | preoperative cardiac variables of diastolic dysfunction and clinical outcomes in lung transplant recipients |
| url | http://dx.doi.org/10.1155/2013/391620 |
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