XMRV Discovery and Prostate Cancer-Related Research
Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Advances in Virology |
| Online Access: | http://dx.doi.org/10.1155/2011/432837 |
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| _version_ | 1832566518248898560 |
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| author | David E. Kang Michael C. Lee Jaydip Das Gupta Eric A. Klein Robert H. Silverman |
| author_facet | David E. Kang Michael C. Lee Jaydip Das Gupta Eric A. Klein Robert H. Silverman |
| author_sort | David E. Kang |
| collection | DOAJ |
| description | Xenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. The principal confounding factors are the near ubiquitous presence of mouse-derived reagents, antibodies and cells, and often XMRV itself, in laboratories. XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. Here, we will review the discovery of XMRV and then focus on prostate cancer-related research involving this intriguing virus. |
| format | Article |
| id | doaj-art-f8d0e67b970042d89ce1aa1d38f4a837 |
| institution | Kabale University |
| issn | 1687-8639 1687-8647 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Virology |
| spelling | doaj-art-f8d0e67b970042d89ce1aa1d38f4a8372025-02-03T01:04:02ZengWileyAdvances in Virology1687-86391687-86472011-01-01201110.1155/2011/432837432837XMRV Discovery and Prostate Cancer-Related ResearchDavid E. Kang0Michael C. Lee1Jaydip Das Gupta2Eric A. Klein3Robert H. Silverman4Glickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USAGlickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USADepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USAGlickman Urological and Kidney Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USADepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USAXenotropic murine leukemia virus-related virus (XMRV) was first reported in 2006 in a study of human prostate cancer patients with genetic variants of the antiviral enzyme, RNase L. Subsequent investigations in North America, Europe, Asia, and Africa have either observed or failed to detect XMRV in patients (prostate cancer, chronic fatigue syndrome-myalgic encephalomyelitis (CFS-ME), and immunosuppressed with respiratory tract infections) or normal, healthy, control individuals. The principal confounding factors are the near ubiquitous presence of mouse-derived reagents, antibodies and cells, and often XMRV itself, in laboratories. XMRV infects and replicates well in many human cell lines, but especially in certain prostate cancer cell lines. XMRV also traffics to prostate in a nonhuman primate model of infection. Here, we will review the discovery of XMRV and then focus on prostate cancer-related research involving this intriguing virus.http://dx.doi.org/10.1155/2011/432837 |
| spellingShingle | David E. Kang Michael C. Lee Jaydip Das Gupta Eric A. Klein Robert H. Silverman XMRV Discovery and Prostate Cancer-Related Research Advances in Virology |
| title | XMRV Discovery and Prostate Cancer-Related Research |
| title_full | XMRV Discovery and Prostate Cancer-Related Research |
| title_fullStr | XMRV Discovery and Prostate Cancer-Related Research |
| title_full_unstemmed | XMRV Discovery and Prostate Cancer-Related Research |
| title_short | XMRV Discovery and Prostate Cancer-Related Research |
| title_sort | xmrv discovery and prostate cancer related research |
| url | http://dx.doi.org/10.1155/2011/432837 |
| work_keys_str_mv | AT davidekang xmrvdiscoveryandprostatecancerrelatedresearch AT michaelclee xmrvdiscoveryandprostatecancerrelatedresearch AT jaydipdasgupta xmrvdiscoveryandprostatecancerrelatedresearch AT ericaklein xmrvdiscoveryandprostatecancerrelatedresearch AT roberthsilverman xmrvdiscoveryandprostatecancerrelatedresearch |