Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review
BackgroundAnti-synthetase syndrome (ASS) is a rare autoimmune myopathy and forms part of the idiopathic inflammatory myopathies (IIMs). A distinctive feature of ASS is the presence of anti-aminoacyl tRNA synthase (ARS) antibodies, which target synthetases, leading to inflammation in muscles, lungs,...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525432/full |
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| author | Jia Liu Nana Nie Ranran Zhang Dahai Wang Yi Lin Hong Chang |
| author_facet | Jia Liu Nana Nie Ranran Zhang Dahai Wang Yi Lin Hong Chang |
| author_sort | Jia Liu |
| collection | DOAJ |
| description | BackgroundAnti-synthetase syndrome (ASS) is a rare autoimmune myopathy and forms part of the idiopathic inflammatory myopathies (IIMs). A distinctive feature of ASS is the presence of anti-aminoacyl tRNA synthase (ARS) antibodies, which target synthetases, leading to inflammation in muscles, lungs, and other tissues.Case presentationA case of a 12-year-old Chinese girl with recurrent fever, myalgia, and Gottron’s papules is reported. Serum creatine kinase was markedly elevated, and chest CT revealed interstitial changes. Magnetic Resonance Imaging (MRI) of the left thigh indicated soft tissue swelling and interstitial fluid accumulation. Electromyography demonstrated myogenic injury. Pathological examination of a left thigh muscle biopsy revealed local edema, focal lymphocyte infiltration, and proliferation and dilation of interstitial small vessels. The myositis antibody spectrum test was positive for anti-PL-7 antibodies. Treatment with glucocorticoids and methotrexate led to significant improvement in her condition.ConclusionThis case represents the youngest reported patient with PL-7 positive ASS to date. |
| format | Article |
| id | doaj-art-f8c9ffe578644c519b00098bc3cd9327 |
| institution | DOAJ |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-f8c9ffe578644c519b00098bc3cd93272025-08-20T02:55:35ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-03-011610.3389/fimmu.2025.15254321525432Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature reviewJia LiuNana NieRanran ZhangDahai WangYi LinHong ChangBackgroundAnti-synthetase syndrome (ASS) is a rare autoimmune myopathy and forms part of the idiopathic inflammatory myopathies (IIMs). A distinctive feature of ASS is the presence of anti-aminoacyl tRNA synthase (ARS) antibodies, which target synthetases, leading to inflammation in muscles, lungs, and other tissues.Case presentationA case of a 12-year-old Chinese girl with recurrent fever, myalgia, and Gottron’s papules is reported. Serum creatine kinase was markedly elevated, and chest CT revealed interstitial changes. Magnetic Resonance Imaging (MRI) of the left thigh indicated soft tissue swelling and interstitial fluid accumulation. Electromyography demonstrated myogenic injury. Pathological examination of a left thigh muscle biopsy revealed local edema, focal lymphocyte infiltration, and proliferation and dilation of interstitial small vessels. The myositis antibody spectrum test was positive for anti-PL-7 antibodies. Treatment with glucocorticoids and methotrexate led to significant improvement in her condition.ConclusionThis case represents the youngest reported patient with PL-7 positive ASS to date.https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525432/fullanti-synthetase syndromeanti-PL-7 antibodymyositiscase reportILD |
| spellingShingle | Jia Liu Nana Nie Ranran Zhang Dahai Wang Yi Lin Hong Chang Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review Frontiers in Immunology anti-synthetase syndrome anti-PL-7 antibody myositis case report ILD |
| title | Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review |
| title_full | Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review |
| title_fullStr | Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review |
| title_full_unstemmed | Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review |
| title_short | Anti-synthetase syndrome with anti-PL-7 antibody positive in a child: a case report and literature review |
| title_sort | anti synthetase syndrome with anti pl 7 antibody positive in a child a case report and literature review |
| topic | anti-synthetase syndrome anti-PL-7 antibody myositis case report ILD |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1525432/full |
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